DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and nmbr

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	XP_690325.2	Gene:	nmbr / 561834	ZFINID:	ZDB-GENE-041014-369	Length:	372	Species:	Danio rerio

Alignment Length:	349	Identity:	103/349 - (29%)
Similarity:	175/349 - (50%)	Gaps:	33/349 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 ISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVIIGLFCIPFQFQAALLQSWNLPWFMCS 109
            |..|.::||..::.:..||..||:|.|::|::||..|:::.:.|:|........:.|......|.
Zfish    42 IITVGLLGNITLVKIFITTSAMRSVPNIFISSLAVGDLLLLVTCVPVDAFRYFYEEWIFGTVACK 106

  Fly   110 FCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRARPTKFV----SKFIIGGIWMLALLFAVPFAI 170
            ..|.:|..||.||||||||::.|||:||:||:..:.:..|    .|.|.  ||::::|.|:|.|:
Zfish   107 MIPVIQLTSVGVSVFTLTALSADRHKAIVNPMDIQSSSAVFWTCLKAIT--IWVVSVLLAIPEAV 169

  Fly   171 AFRVEELTERFRENNETYNVTRPFCMNKNLSDDQLQSFRYTLVF-VQYLVPFCVISFVYIQMAVR 234
            ..:|..:.::        |.|...|:...||::........::| |.:|:|..:||..|..:|..
Zfish   170 FSQVVHMPDK--------NTTFTACVPYPLSNEMHPKIHSIMIFLVYFLIPLSIISVYYYHIART 226

  Fly   235 LWGTR--APGN-AQDSRDITLLKNKKKVIKMLIIVVIIFGLCWLP---LQLY-NILYVTIPEIND 292
            |..:.  .||. ::.|:..|  :.:|::.|::::.|.:|.|||.|   |.:| :..|..|.....
Zfish   227 LIKSAHDMPGEISEHSKRQT--ETRKRLAKIVLVFVGLFALCWFPNHVLYMYRSFNYRQIDSSLS 289

  Fly   293 YHFISIVWFCCDWLAMSNSCYNPFIYGIYNEKFKREFNKRFAACFCKFKTSMDAHERTFSMHTRA 357
            :..|::|   ...|:.|:||.|||...:.:|.|:|.||.:......|::      ||..|.....
Zfish   290 HLIITLV---ARVLSFSSSCVNPFALYLLSESFRRHFNNQLLCRQRKYQ------ERNTSYLQST 345

  Fly   358 SSIRSTYANSSMRIRSNLFGPARG 381
            |:||.|....|....:|..|..:|
Zfish   346 SAIRMTSIRKSTPAVANGHGQKQG 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	88/294 (30%)
		7tm_1	52..318	CDD:278431	84/277 (30%)
		PHA03216	467..>519	CDD:177558
nmbr	XP_690325.2	7tm_1	49..310	CDD:278431	82/275 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910