DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and npffr2a

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001098579.1	Gene:	npffr2a / 560955	ZFINID:	ZDB-GENE-060526-183	Length:	422	Species:	Danio rerio

Alignment Length:	436	Identity:	133/436 - (30%)
Similarity:	213/436 - (48%)	Gaps:	56/436 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AMDL---IEQESRLEFLPGAEE------EAEFERLYAAPAEIVALLSIFYGGISIVAVIGNTLVI 57
            ::||   :..:....|:.|:.|      ...:...|.....:.|:..:.|..|.:|.:|||.:|.
Zfish     4 SLDLNITLVDDGNWTFINGSSEFFLPLNNITYVGYYLHQPSVAAVFIVSYLLIFLVCMIGNGVVC 68

  Fly    58 WVVATTRQMRTVTNMYIANLAFADVIIGLFCIPFQFQAALLQSWNLPWFMCSFCPFVQALSVNVS 122
            ::|..::.||||||::|.|||.:|:::|:||:|......::..|.....:|.....||.:||:.|
Zfish    69 FIVLRSKNMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIITGWPFGSMVCKMSGMVQGISVSAS 133

  Fly   123 VFTLTAIAIDRHRAIINPLRARPTKFVSKFIIGGIWMLALLFAVPFAIAFRV--EELTERFRENN 185
            ||||.|||:||.|.|:.|.:.:.|...:.|||..||:||:....|..:..:|  |:....||.||
Zfish   134 VFTLVAIAVDRFRCIVYPFKQKLTISTATFIIVIIWVLAVSIMCPSGVMLQVTKEQNIRVFRGNN 198

  Fly   186 ETYNVTRPF--CMNKNLSDDQLQSFRYTLVFVQ-YLVPFCVISFVYIQMAVRLWGTRAPGNAQDS 247
            .    :.||  | .:|..:.:::....|::|.. ||.|..:|..:|.::.:.|:.|..|...:..
Zfish   199 R----SSPFYWC-RENWPNQEMRKIYTTVLFANIYLAPLSLIVIMYARIGITLFKTAMPAGGKHG 258

  Fly   248 RD--ITLLKNKKKVIKMLIIVVIIFGLCWLPLQLYNIL--YVTIPEINDYHFISI-VWFCCDWLA 307
            .|  .::.|.|::|||||:||.::|.|.||||....:|  ||.:.| :.|..|:| ::....|||
Zfish   259 HDNRHSVSKKKQRVIKMLLIVALLFILSWLPLWTLMMLTDYVKLTE-HQYRVINIYIYPFAHWLA 322

  Fly   308 MSNSCYNPFIYGIYNEKFKREFNKRFAACFCKFKTSMDAHERTFSMHTRASSIRSTYANSSMRIR 372
            ..||..||.|||.:||.|:|.|...|....|    .:....||:|...:.:|::..
Zfish   323 FFNSSVNPIIYGFFNENFRRGFQAIFKFGLC----PVGGQHRTYSHRVQGNSVQPV--------- 374

  Fly   373 SNLFGPARGGVNNGKPGLHMPRVHGSGANSGIYNGSSGQNNNVNGQ 418
             ||                .|.......|| :.|.||.:.|::|.|
Zfish   375 -NL----------------QPSTEPISLNS-LENNSSRRMNHINEQ 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	106/292 (36%)
		7tm_1	52..318	CDD:278431	97/275 (35%)
		PHA03216	467..>519	CDD:177558
npffr2a	NP_001098579.1	7tm_4	57..>184	CDD:304433	49/126 (39%)
npffr2a	NP_001098579.1	7tm_1	63..333	CDD:278431	97/275 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910