DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and npffr1l1

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001165167.1	Gene:	npffr1l1 / 559950	ZFINID:	ZDB-GENE-091118-18	Length:	398	Species:	Danio rerio

Alignment Length:	412	Identity:	129/412 - (31%)
Similarity:	200/412 - (48%)	Gaps:	60/412 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LYAAPAEIVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVIIGLFCIPF 91
            :::|...:..:||  |..:.::.|:||.||..||...|.||:|||::|.|||.:|:::|:||:|.
Zfish    25 IHSAGMAVSYILS--YLLVLLLCVVGNGLVCLVVIRNRNMRSVTNLFILNLAVSDLLVGIFCVPT 87

  Fly    92 QFQAALLQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRARPTKFVSKFIIGG 156
            ....:|:..|......|:....||.:||:.|||||.|||:||...|:.|...|.....:.|.|..
Zfish    88 TLIDSLISGWPFSQITCTMSNLVQGMSVSASVFTLVAIAVDRFTGIVYPFHHRLRPVTALFAIVF 152

  Fly   157 IWMLALLFAVPFAIAFRVEELTERFR-ENNETYNVTRPFCMNKNLSDDQLQSFRYTLVFVQ-YLV 219
            ||:||.....|.|....|..|.:.:. :|::.|.:   |...::.....::....|::||. ||.
Zfish   153 IWLLAFAIIFPSAATLTVIHLDDMYMVQNDQIYPL---FVCFEDWPRADMRRVYTTVIFVHVYLA 214

  Fly   220 PFCVISFVYIQMAVRLWGTRAPGNAQDSRDITLLKNKK--KVIKMLIIVVIIFGLCWLPLQLYNI 282
            |..:||.:|..:|.:|     ..|.|::|    |::::  |||||||:|.::|.:.||||.
Zfish   215 PLGLISIMYGCIAAKL-----SSNLQENR----LRSRRRMKVIKMLIMVAVLFMVSWLPLW---- 266

  Fly   283 LYVTIPEINDYH--------FISIVWF-CCDWLAMSNSCYNPFIYGIYNEKFKREFNKRFAACFC 338
               |:..:.||.        |:|...| ...|||..||..||.|||.:||.|:|.|.   ||..|
Zfish   267 ---TLMLLTDYQDLDRQQIDFLSSYLFPVAHWLAFFNSGVNPIIYGFFNENFRRGFQ---AAVAC 325

  Fly   339 KFKTSMDAHERTFSMHTRASSIRSTYANSSMRIRSNLFGPARGGVNNGKPGLHMPRV-HGSGANS 402
            .|.:|:            ||.:|.|:   .:....|.......||.:|:.....|.: ||:.
Zfish   326 GFCSSV------------ASEMRHTH---FVLPPPNKVSDGSRGVTSGRKERCFPVIPHGAA--- 372

  Fly   403 GIYNGSSG-QNNNVNGQHHQHQ 423
               :|..| ...::||....|:
Zfish   373 ---HGIQGILLEDMNGTVASHR 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	103/295 (35%)
		7tm_1	52..318	CDD:278431	95/278 (34%)
		PHA03216	467..>519	CDD:177558
npffr1l1	NP_001165167.1	7tm_4	48..319	CDD:304433	102/289 (35%)
npffr1l1	NP_001165167.1	7tm_1	48..308	CDD:278431	95/278 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	198	1.000	Inparanoid score	I3767
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.960