DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and NPY1R

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_000900.1	Gene:	NPY1R / 4886	HGNCID:	7956	Length:	384	Species:	Homo sapiens

Alignment Length:	354	Identity:	114/354 - (32%)
Similarity:	186/354 - (52%)	Gaps:	48/354 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PAEIVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVIIGLFCIPFQFQA 95
            |..::..|::.||.:.|:.|.||..:|.::...::||.|||:.|.||:|:|:::.:.|:||.|..
Human    36 PLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVY 100

  Fly    96 ALLQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRARPTKFVSKFIIGGIWML 160
            .|:..|.....||...||||.:|:.||:|:|..||::||:.||||...||....:...|..||:|
Human   101 TLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVL 165

  Fly   161 ALLFAVPFAIAFRVEELT-ERFRENNETYNVT------RPFCMNKNLSDDQLQSFRYTLVFVQYL 218
            |:..::||.|   .:.:| |.|:      |||      :..|.::..||....|:...|:.:||.
Human   166 AVASSLPFLI---YQVMTDEPFQ------NVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYF 221

  Fly   219 VPFCVISFVYIQMAVRLWGTRAPGNAQDS-RDITLLKNK------KKVIKMLIIVVIIFGLCWLP 276
            .|.|.|...|.::.:||   :...|..|. ||     ||      |::..||:.:|:.|.:||||
Human   222 GPLCFIFICYFKIYIRL---KRRNNMMDKMRD-----NKYRSSETKRINIMLLSIVVAFAVCWLP 278

  Fly   277 LQLYNILYVTIPEINDY-HFI------SIVWFCCDWLAMSNSCYNPFIYGIYNEKFKREFNKRFA 334
            |.::|.::       |: |.|      ::::..|...||.::|.||..||..|:.|:|:.  :|.
Human   279 LTIFNTVF-------DWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDL--QFF 334

  Fly   335 ACFCKFKTSMDAHERTFSMHTRASSIRST 363
            ..||.|::..|.:| |.:|.|..:.:..|
Human   335 FNFCDFRSRDDDYE-TIAMSTMHTDVSKT 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	100/303 (33%)
		7tm_1	52..318	CDD:278431	93/286 (33%)
		PHA03216	467..>519	CDD:177558
NPY1R	NP_000900.1	7tm_4	52..>176	CDD:304433	50/126 (40%)
NPY1R	NP_000900.1	7tm_1	57..320	CDD:278431	93/286 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5959
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860