DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and npy7r

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001007219.1	Gene:	npy7r / 449010	ZFINID:	ZDB-GENE-040924-9	Length:	372	Species:	Danio rerio

Alignment Length:	364	Identity:	115/364 - (31%)
Similarity:	179/364 - (49%)	Gaps:	58/364 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVIIGLFCIPFQFQAALLQSWN 102
            |.:.|..|.::.::||||||:::...|.||||||.:|||||.||:::...|:||.....||..|.
Zfish    50 LILAYSLIILLGLVGNTLVIYMIILYRNMRTVTNYFIANLALADLMVDTVCLPFTLVYTLLDEWK 114

  Fly   103 LPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRARPTKFVSKFIIGGIWMLALLFAVP 167
            ....||...|:.|||||:||:.|||.||::|:|.|:..|..|..:..|..|||..|..|.:.|.|
Zfish   115 FGAVMCHMVPYSQALSVHVSILTLTIIALERYRCIVFHLGQRLNRCTSFIIIGLTWAFAAILAGP 179

  Fly   168 FAI--AFRVEELTERFRENNETYNVTRPF-------CMNK--NLSDDQLQSFRYTLVFVQYLVPF 221
            .||  .:|.||:               |:       |..|  |.::.....:..:::.:||:||.
Zfish   180 LAIFREYRYEEI---------------PYIDLRIAVCSEKWPNGTNRDAVIYSLSMLLLQYVVPL 229

  Fly   222 CVISFVYIQMAVRLWGTRAPGNAQDSRDITLLKNKKKVIKMLIIVVIIFGLCWLPLQLYNIL--Y 284
            .:||:.|:.:.::|....:|.|..|.     :..:||..|||.:||::|.:||||..::.:.  .
Zfish   230 AIISYAYVCIWIKLKNHVSPSNRNDG-----IVRRKKTTKMLALVVVVFAVCWLPFHMFQLASDL 289

  Fly   285 VTIPEINDYHFISIVWFCCDWLAMSNSCYNPFIYGIYNEKFKREFNKRFAACFCKFKTSMDAHER 349
            ..|.:..:|..|..::..   :||.::..||.:||..|:.::..|...|.   |:.|..
Zfish   290 DLILKFKEYKLIYTLFHI---VAMCSTFVNPLLYGWMNQNYRNGFLMFFR---CEHKPD------ 342

  Fly   350 TFSMHTRASSIRSTYANSSMRIRSNLFGPARGGVNNGKP 388
                        |.|.:.|.|.|| |.|....|.|:|:|
Zfish   343 ------------SIYPDGSFRTRS-LRGMIVNGYNDGQP 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	96/295 (33%)
		7tm_1	52..318	CDD:278431	93/278 (33%)
		PHA03216	467..>519	CDD:177558
npy7r	NP_001007219.1	7tm_GPCRs	48..331	CDD:333717	99/303 (33%)
		TM helix 1	50..74	CDD:320095	9/23 (39%)
		TM helix 2	83..105	CDD:320095	11/21 (52%)
		TM helix 3	121..143	CDD:320095	12/21 (57%)
		TM helix 4	164..180	CDD:320095	6/15 (40%)
		TM helix 5	214..237	CDD:320095	6/22 (27%)
		TM helix 6	260..285	CDD:320095	12/24 (50%)
		TM helix 7	299..324	CDD:320095	7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910