DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and CCHa2-R

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001356958.1	Gene:	CCHa2-R / 35535	FlyBaseID:	FBgn0033058	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	403	Identity:	122/403 - (30%)
Similarity:	189/403 - (46%)	Gaps:	39/403 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVIIGLFCIPFQFQAALLQSW 101
            ::::.|..|.||.|:||..::.:....|.||.:.|.||.:||.||:::.|.|:|........:||
  Fly    71 IVTVLYTLIFIVGVLGNGTLVIIFFRHRSMRNIPNTYILSLALADLLVILVCVPVATIVYTQESW 135

  Fly   102 NLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRARPTKFVSKFIIGGIWMLALLFAV 166
            .....||....|.:.:|:.||||||||::.:|:.||:||||...||.::.|....||:||:|..:
  Fly   136 PFERNMCRISEFFKDISIGVSVFTLTALSGERYCAIVNPLRKLQTKPLTVFTAVMIWILAILLGM 200

  Fly   167 PFAIAFRVEELTERFRENNETYNVTRPFCMNKNLSDDQLQSFRYT-LVFVQYLVPFCVISFVYIQ 230
            |..:...::.........|.|..|..||      .|.:...|... ...|.||:|..:|..:||.
  Fly   201 PSVLFSDIKSYPVFTATGNMTIEVCSPF------RDPEYAKFMVAGKALVYYLLPLSIIGALYIM 259

  Fly   231 MAVRLW--GTRAPGNAQDSRDITLLKNKKKVIKMLIIVVIIFGLCWLPLQLYNILYVTIPEIND- 292
            ||.||.  ....||..|..:..|..:.:..|.:|::..|::|.:|:.|..::.:.|...|...:
  Fly   260 MAKRLHMSARNMPGEQQSMQSRTQARARLHVARMVVAFVVVFFICFFPYHVFELWYHFYPTAEED 324

  Fly   293 ----YHFISIVWFCCDWLAMSNSCYNPFIYGIYNEKFKREFNKRFAACFC-KFKTSMDAHERTFS 352
                ::.:.||.||..:|   |||.||......:..|::.|| |:..|.| |.:..:..|.....
  Fly   325 FDEFWNVLRIVGFCTSFL---NSCVNPVALYCVSGVFRQHFN-RYLCCICVKRQPHLRQHSTATG 385

  Fly   353 MHTRASSI---RSTYANSSM-RIRSNLF-----------GPARGGVNNGKPG-LH----MPRVHG 397
            |....|.:   ||||...:. .:|::|.           |...|||.:|:.| .|    ||..||
  Fly   386 MMDNTSVMSMRRSTYVGGTAGNLRASLHRNSNHGVGGAGGGVGGGVGSGRVGSFHRQDSMPLQHG 450

  Fly   398 SGANSGIYNGSSG 410
            :....|...||||
  Fly   451 NAHGGGAGGGSSG 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	89/290 (31%)
		7tm_1	52..318	CDD:278431	85/273 (31%)
		PHA03216	467..>519	CDD:177558
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	91/299 (30%)
		TM helix 1	71..97	CDD:320593	7/25 (28%)
		TM helix 2	104..130	CDD:320593	10/25 (40%)
		TM helix 3	142..172	CDD:320593	13/29 (45%)
		TM helix 4	182..202	CDD:320593	6/19 (32%)
		TM helix 5	234..259	CDD:320593	7/24 (29%)
		TM helix 6	285..315	CDD:320593	6/29 (21%)
		TM helix 7	330..355	CDD:320593	10/27 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4219
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45695
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910