DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and Gpr165

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001100052.1	Gene:	Gpr165 / 296866	RGDID:	1564566	Length:	462	Species:	Rattus norvegicus

Alignment Length:	380	Identity:	96/380 - (25%)
Similarity:	172/380 - (45%)	Gaps:	60/380 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDLIEQESRLEFLPGAEEEAEFERLYAAPAEIVALLSIFYGGISIVAVIGNTLVIWVVATTRQMR 67
            ::::.|:.:::|                      .|.:.|..:...|:|||.::..::...:::.
  Rat    92 LEIVSQDEQVQF----------------------WLVVGYTIVVFAAIIGNWVLNHIIMKYKRVH 134

  Fly    68 TVTNMYIANLAFADVIIGLFCIPFQFQAALLQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAID 132
            |.|.:::.|::..::::.|...||.....|..|.......|....|.|.....|:|.::.||::|
  Rat   135 TATGLFVVNISVTNMMLALLSSPFTMVRYLCNSLVFGKMTCHLSRFAQYSCAYVTVMSMAAISLD 199

  Fly   133 RHRAIINPLRARPTKFVSKFIIGGIWMLALLFAVPFAIAFRVEELTERFRENNETYNVTRPFCMN 197
            |||.::.||:||.|.......|..||:::...|:|.|:..::.::        |..|.|.....
  Rat   200 RHRVMLYPLKARITPMQGNVCIIIIWIVSTCAALPHAVYQKLYQV--------EFGNTTEESAC- 255

  Fly   198 KNLSDDQLQSFRYT-------------LVFVQYLVPFCVISFVYIQMAVRLWGTRAPGNAQDSRD 249
                   |.||.||             |:|  :::|..|:..||..:|.:||...|..:......
  Rat   256 -------LPSFPYTSKSTWKYLDLGTFLLF--FILPLLVLVAVYGHVAKKLWIHDAVDDINIHTY 311

  Fly   250 ITLLKNKKKVIKMLIIVVIIFGLCWLPLQLYNILYVTIPEINDYHFISIVWFCCDWLAMSNSCYN 314
            |.....||:.:|||:.||:::.:.||||.||.:| ::...|:.::.:   :|...|||:|:||||
  Rat   312 ICQRGKKKQTLKMLMTVVLLYTISWLPLNLYLVL-LSSESISSHNGL---YFFLHWLAISSSCYN 372

  Fly   315 PFIYGIYNEKFKREFNKRFAACFCKFKTSMDAHERTFSMHTRASSIRSTYANSSM 369
            |:||...::.|:.|..|.....   .|..:|...|....|.|.||:..|....|:
  Rat   373 PYIYCWLSDSFRIEVQKVIMEI---QKMLLDKISRLRGEHRRLSSVSHTQTPGSV 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	81/295 (27%)
		7tm_1	52..318	CDD:278431	76/278 (27%)
		PHA03216	467..>519	CDD:177558
Gpr165	NP_001100052.1	7tmA_GPR83	103..387	CDD:320511	84/327 (26%)
		TM helix 1	105..129	CDD:320511	6/23 (26%)
		TM helix 2	138..160	CDD:320511	4/21 (19%)
		TM helix 3	176..198	CDD:320511	6/21 (29%)
		TM helix 4	219..235	CDD:320511	4/15 (27%)
		TM helix 5	268..291	CDD:320511	5/24 (21%)
		TM helix 6	322..344	CDD:320511	11/21 (52%)
		TM helix 7	355..380	CDD:320511	12/27 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1254727at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X257
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920