DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and Tacr1

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_036799.1	Gene:	Tacr1 / 24807	RGDID:	3811	Length:	407	Species:	Rattus norvegicus

Alignment Length:	331	Identity:	103/331 - (31%)
Similarity:	161/331 - (48%)	Gaps:	24/331 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EFLPGAEEEAEFERLYAAPAEIVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANL 77
            :..|...........:..|...:.|.:..|..|.:.:|:||.:|||::...::||||||.::.||
  Rat    10 DLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNL 74

  Fly    78 AFADVIIGLFCIPFQFQAALLQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLR 142
            |||:..:..|.....|..|:...|....|.|.|..|....::..|::::||:|.||:.|||:||:
  Rat    75 AFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQ 139

  Fly   143 ARPTKFVSKFIIGGIWMLALLFAVPFAIAFRVEELTERF-------RENNETYNVTRPFCMNKNL 200
            .|.:...:|.:|..||:||||.|.|.......|.:..|.       ...|.||......|:.
  Rat   140 PRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVT--- 201

  Fly   201 SDDQLQSFRYTLVFVQYLVPFCVISFVYIQMAVRLWGTRAPGNAQDSRDITLLKNKKKVIKMLII 265
                        |.: |.:|..||.:.|..:.:.||.:..||::.| |....:..|:||:||:|:
  Rat   202 ------------VLI-YFLPLLVIGYAYTVVGITLWASEIPGDSSD-RYHEQVSAKRKVVKMMIV 252

  Fly   266 VVIIFGLCWLPLQLYNILYVTIPEINDYHFISIVWFCCDWLAMSNSCYNPFIYGIYNEKFKREFN 330
            ||..|.:||||..::.:|....|::....||..|:....|||||::.|||.||...|::|:..|.
  Rat   253 VVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFK 317

  Fly   331 KRFAAC 336
            ..|..|
  Rat   318 HAFRCC 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	95/289 (33%)
		7tm_1	52..318	CDD:278431	90/272 (33%)
		PHA03216	467..>519	CDD:177558
Tacr1	NP_036799.1	7tm_1	54..305	CDD:278431	87/267 (33%)
Tacr1	NP_036799.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..407
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X257
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810