DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lkr and Prokr2

DIOPT Version :9

Sequence 1:NP_647968.3 Gene:Lkr / 38622 FlyBaseID:FBgn0035610 Length:542 Species:Drosophila melanogaster
Sequence 2:NP_659193.3 Gene:Prokr2 / 246313 MGIID:2181363 Length:381 Species:Mus musculus


Alignment Length:352 Identity:97/352 - (27%)
Similarity:174/352 - (49%) Gaps:39/352 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 LP-GAEEEAEFERLYAAPAEIVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLA 78
            || |.:|:....:.:.| |:||  :.:...||.:|..|||.:.|..:|..:::|.:||:.|||||
Mouse    32 LPLGEDEDVTKTQTFFA-AKIV--IGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLA 93

  Fly    79 FADVIIGLFCIPFQFQAALLQ--SWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPL 141
            .:|.::.:.|.||:....:::  ||.....:|:...:::.:|:.||...|.||||||:.||::||
Mouse    94 ISDFLVAIVCCPFEMDYYVVRQLSWAHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPL 158

  Fly   142 RARPTKFVSKFIIGGIWMLALLFAVPFAIAFRVEELTERFRENNETYNVTRPFCMNKNLSDDQLQ 206
            :.|.....:.|:|..:||:::|.|||.|. |..|.:....:      |..:.||......|.||.
Mouse   159 KPRMNYQTASFLIALVWMVSILIAVPSAY-FTTETILVIVK------NQEKIFCGQIWSVDQQLY 216

  Fly   207 SFRYTL-VF-VQYLVPFCVISFVYIQMAVRLWGTRAPGNAQDSRDITLLKNKKKVIKMLIIVVII 269
            ...|.| || ::::.|...::..|.:::..||....|| .|..:....|:.::|.:.:|:.::..
Mouse   217 YKSYFLFVFGLEFVGPVVTMTLCYARISQELWFKAVPG-FQTEQIRKRLRCRRKTVLLLMGILTA 280

  Fly   270 FGLCWLPLQLYNILYVTIPE--INDYHFISIVWFCCDWLAMSNSCYNPFIYGIYNEKFKREFNKR 332
            :.|||.|...:.|:....|.  :.:.|::: .::..:.:|||||..|                  
Mouse   281 YVLCWAPFYGFTIVRDFFPTVVVKEKHYLT-AFYVVECIAMSNSMIN------------------ 326

  Fly   333 FAACFCKFK-TSMDAHERTFSMHTRAS 358
             ..||...| .:|...::...:|.|.|
Mouse   327 -TICFVTVKNNTMKYFKKMLRLHWRPS 352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LkrNP_647968.3 7tm_4 46..329 CDD:304433 80/288 (28%)
7tm_1 52..318 CDD:278431 78/271 (29%)
PHA03216 467..>519 CDD:177558
Prokr2NP_659193.3 7tmA_prokineticin-R 51..341 CDD:320332 88/319 (28%)
TM helix 1 52..78 CDD:320332 9/27 (33%)
TM helix 2 85..110 CDD:320332 11/24 (46%)
TM helix 3 125..155 CDD:320332 12/29 (41%)
TM helix 4 166..187 CDD:320332 8/20 (40%)
TM helix 5 217..246 CDD:320332 6/28 (21%)
TM helix 6 265..295 CDD:320332 7/29 (24%)
TM helix 7 309..334 CDD:320332 8/44 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
21.870

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