DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lkr and Prlhr

DIOPT Version :9

Sequence 1:NP_647968.3 Gene:Lkr / 38622 FlyBaseID:FBgn0035610 Length:542 Species:Drosophila melanogaster
Sequence 2:NP_963909.2 Gene:Prlhr / 226278 MGIID:2135956 Length:370 Species:Mus musculus


Alignment Length:325 Identity:102/325 - (31%)
Similarity:171/325 - (52%) Gaps:25/325 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 LPGAEEEAEFERLYAAPAEIVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAF 79
            :|.|.....|:.|... .::..|:.:.|..:.:|.::||.|::.|:|..|::..|||..|.|||.
Mouse    41 VPRAAAVTPFQSLQLV-HQLKGLIVMLYSIVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLAL 104

  Fly    80 ADVIIGLFCIPFQFQAAL-LQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRA 143
            :||::...|:|.....|. .:.|.....:|....|:|.::|.|||||||.||:||:..:::|||.
Mouse   105 SDVLMCAACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIALDRYVVLVHPLRR 169

  Fly   144 RPTKFVSKFIIGGIWMLALLFAVPFAI-AFRVE------ELTERFRENNETYNVTRPFCMNKNLS 201
            |.:..:|.:.:.|||.|:.:.|:|.|: .:.||      .|.|.|..:.|.              
Mouse   170 RISLRLSAYAVLGIWALSAVLALPAAVHTYHVELKPHDVSLCEEFWGSQER-------------- 220

  Fly   202 DDQLQSFRYTLVFVQYLVPFCVISFVYIQMAVRLWGTRAPGNAQDSRDITLLKNKKKVIKMLIIV 266
              |.|.:.:.|:...||:|...|...|::::|:|.....||:...|:.......:::...:|::|
Mouse   221 --QRQIYAWGLLLGTYLLPLLAILLSYVRVSVKLRNRVVPGSVTQSQADWDRARRRRTFCLLVVV 283

  Fly   267 VIIFGLCWLPLQLYNILYVTIPEINDYHFISIVWFCCDWLAMSNSCYNPFIYGIYNEKFKREFNK 331
            |::|.:|||||.::|:|....|...|.:...:|...|.|||||::|||||||...::.|:.|..|
Mouse   284 VVVFAVCWLPLHIFNLLRDLDPRAIDPYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRK 348

  Fly   332  331
            Mouse   349  348

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LkrNP_647968.3 7tm_4 46..329 CDD:304433 94/290 (32%)
7tm_1 52..318 CDD:278431 90/273 (33%)
PHA03216 467..>519 CDD:177558
PrlhrNP_963909.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
7tmA_PrRP_R 61..346 CDD:320516 96/300 (32%)
TM helix 1 62..88 CDD:320516 8/25 (32%)
TM helix 2 95..120 CDD:320516 10/24 (42%)
TM helix 3 134..164 CDD:320516 15/29 (52%)
TM helix 4 175..196 CDD:320516 7/20 (35%)
TM helix 5 222..251 CDD:320516 7/28 (25%)
TM helix 6 271..301 CDD:320516 10/29 (34%)
TM helix 7 314..339 CDD:320516 14/24 (58%)
Required for interaction with GRIP1, GRIP2 and PICK1. /evidence=ECO:0000250 365..370
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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