DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lkr and Tacr1

DIOPT Version :9

Sequence 1:NP_647968.3 Gene:Lkr / 38622 FlyBaseID:FBgn0035610 Length:542 Species:Drosophila melanogaster
Sequence 2:NP_033339.2 Gene:Tacr1 / 21336 MGIID:98475 Length:407 Species:Mus musculus


Alignment Length:331 Identity:103/331 - (31%)
Similarity:161/331 - (48%) Gaps:24/331 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 EFLPGAEEEAEFERLYAAPAEIVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANL 77
            :..|...........:..|...:.|.:..|..|.:.:|:||.:|||::...::||||||.::.||
Mouse    10 DLFPNTSTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNL 74

  Fly    78 AFADVIIGLFCIPFQFQAALLQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLR 142
            |||:..:..|.....|..|:...|....|.|.|..|....::..|::::||:|.||:.|||:||:
Mouse    75 AFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQ 139

  Fly   143 ARPTKFVSKFIIGGIWMLALLFAVPFAIAFRVEELTERF-------RENNETYNVTRPFCMNKNL 200
            .|.:...:|.:|..||:||||.|.|.......|.:..|.       ...|.||......|:.   
Mouse   140 PRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVT--- 201

  Fly   201 SDDQLQSFRYTLVFVQYLVPFCVISFVYIQMAVRLWGTRAPGNAQDSRDITLLKNKKKVIKMLII 265
                        |.: |.:|..||.:.|..:.:.||.:..||::.| |....:..|:||:||:|:
Mouse   202 ------------VLI-YFLPLLVIGYAYTVVGITLWASEIPGDSSD-RYHEQVSAKRKVVKMMIV 252

  Fly   266 VVIIFGLCWLPLQLYNILYVTIPEINDYHFISIVWFCCDWLAMSNSCYNPFIYGIYNEKFKREFN 330
            ||..|.:||||..::.:|....|::....||..|:....|||||::.|||.||...|::|:..|.
Mouse   253 VVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFK 317

  Fly   331 KRFAAC 336
            ..|..|
Mouse   318 HAFRCC 323

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LkrNP_647968.3 7tm_4 46..329 CDD:304433 95/289 (33%)
7tm_1 52..318 CDD:278431 90/272 (33%)
PHA03216 467..>519 CDD:177558
Tacr1NP_033339.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20 1/9 (11%)
7tm_GPCRs 33..316 CDD:391938 98/299 (33%)
TM helix 1 35..59 CDD:341315 8/23 (35%)
TM helix 2 68..90 CDD:341315 7/21 (33%)
TM helix 3 106..128 CDD:341315 5/21 (24%)
TM helix 4 149..165 CDD:341315 8/15 (53%)
TM helix 5 194..217 CDD:341315 6/38 (16%)
TM helix 6 244..269 CDD:341315 12/24 (50%)
TM helix 7 284..309 CDD:341315 11/24 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 362..407
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4219
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X257
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.810

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