DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and Prokr2

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_620434.2	Gene:	Prokr2 / 192649	RGDID:	708445	Length:	422	Species:	Rattus norvegicus

Alignment Length:	377	Identity:	97/377 - (25%)
Similarity:	178/377 - (47%)	Gaps:	52/377 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AMDLIEQESRLEFLP-------------GAEEEAEFERLYAAPAEIVALLSIFYGGISIVAVIGN 53
            |.||...:..:..||             ..|:..:.:..:|  |:||  :.:...||.:|..:||
  Rat    49 APDLNPPQDHVSLLPLNYSYGDYDIPLDDDEDVTKTQTFFA--AKIV--IGVALAGIMLVCGVGN 109

  Fly    54 TLVIWVVATTRQMRTVTNMYIANLAFADVIIGLFCIPFQFQAALLQ--SWNLPWFMCSFCPFVQA 116
            .:.|..:|..:::|.:||:.|||||.:|.::.:.|.||:....:::  ||.....:|:...:::.
  Rat   110 FVFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRT 174

  Fly   117 LSVNVSVFTLTAIAIDRHRAIINPLRARPTKFVSKFIIGGIWMLALLFAVPFAIAFRVEELTERF 181
            :|:.||...|.||||||:.||::||:.|.....:.|:|..:||:::|.|:|.|. |..|.:....
  Rat   175 VSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAY-FTTETILVIV 238

  Fly   182 RENNETYNVTRPFCMNKNLSDDQLQSFRYTL-VF-VQYLVPFCVISFVYIQMAVRLWGTRAPGNA 244
            :      |..:.||......|.||....|.| || ::::.|...::..|.:::..||....|| .
  Rat   239 K------NQEKLFCGQIWPVDQQLYYKSYFLFVFGLEFVGPVVTMTLCYARISQELWFKAVPG-F 296

  Fly   245 QDSRDITLLKNKKKVIKMLIIVVIIFGLCWLPLQLYNILYVTIPE--INDYHFISIVWFCCDWLA 307
            |..:....|:.::|.:.:|:.::..:.|||.|...:.|:....|.  :.:.|::: .::..:.:|
  Rat   297 QTEQIRKRLRCRRKTVLLLMGILTAYVLCWAPFYGFTIVRDFFPTLVVKEKHYLT-AFYVVECIA 360

  Fly   308 MSNSCYNPFIYGIYNEKFKREFNKRFAACFCKFK-TSMDAHERTFSMHTRAS 358
            ||||..|                   ..||...| .:|...::...:|.|.|
  Rat   361 MSNSMIN-------------------TICFVTVKNNTMKYFKKMLLLHWRPS 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	78/288 (27%)
		7tm_1	52..318	CDD:278431	77/271 (28%)
		PHA03216	467..>519	CDD:177558
Prokr2	NP_620434.2	7tmA_prokineticin-R	92..382	CDD:320332	86/319 (27%)
		TM helix 1	94..118	CDD:320332	6/23 (26%)
		TM helix 2	127..149	CDD:320332	10/21 (48%)
		TM helix 3	167..189	CDD:320332	6/21 (29%)
		TM helix 4	210..226	CDD:320332	6/15 (40%)
		TM helix 5	259..282	CDD:320332	5/22 (23%)
		TM helix 6	312..334	CDD:320332	5/21 (24%)
		TM helix 7	350..375	CDD:320332	8/44 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	3	2.870