Protein Alignment Lkr and Prokr2

DIOPT Version :10

• Sequence 1: NP_647968.3
• Gene: Lkr / 38622
• FlyBaseID: FBgn0035610
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_620434.2
• Gene: Prokr2 / 192649
• RGDID: 708445
• Length: 422
• Species: Rattus norvegicus
• Alignment Length: 377
• Identity: 97/377 - (25%)
• Similarity: 178/377 - (47%)
• Gaps: 52/377 - (13%)

  Fly     2 AMDLIEQESRLEFLP-------------GAEEEAEFERLYAAPAEIVALLSIFYGGISIVAVIGN 53
            |.||...:..:..||             ..|:..:.:..:|  |:||  :.:...||.:|..:||
  Rat    49 APDLNPPQDHVSLLPLNYSYGDYDIPLDDDEDVTKTQTFFA--AKIV--IGVALAGIMLVCGVGN 109

  Fly    54 TLVIWVVATTRQMRTVTNMYIANLAFADVIIGLFCIPFQFQAALLQ--SWNLPWFMCSFCPFVQA 116
            .:.|..:|..:::|.:||:.|||||.:|.::.:.|.||:....:::  ||.....:|:...:::.
  Rat   110 FVFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRT 174

  Fly   117 LSVNVSVFTLTAIAIDRHRAIINPLRARPTKFVSKFIIGGIWMLALLFAVPFAIAFRVEELTERF 181
            :|:.||...|.||||||:.||::||:.|.....:.|:|..:||:::|.|:|.|. |..|.:....
  Rat   175 VSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAY-FTTETILVIV 238

  Fly   182 RENNETYNVTRPFCMNKNLSDDQLQSFRYTL-VF-VQYLVPFCVISFVYIQMAVRLWGTRAPGNA 244
            :      |..:.||......|.||....|.| || ::::.|...::..|.:::..||....|| .
  Rat   239 K------NQEKLFCGQIWPVDQQLYYKSYFLFVFGLEFVGPVVTMTLCYARISQELWFKAVPG-F 296

  Fly   245 QDSRDITLLKNKKKVIKMLIIVVIIFGLCWLPLQLYNILYVTIPE--INDYHFISIVWFCCDWLA 307
            |..:....|:.::|.:.:|:.::..:.|||.|...:.|:....|.  :.:.|::: .::..:.:|
  Rat   297 QTEQIRKRLRCRRKTVLLLMGILTAYVLCWAPFYGFTIVRDFFPTLVVKEKHYLT-AFYVVECIA 360

  Fly   308 MSNSCYNPFIYGIYNEKFKREFNKRFAACFCKFK-TSMDAHERTFSMHTRAS 358
            ||||..|                   ..||...| .:|...::...:|.|.|
  Rat   361 MSNSMIN-------------------TICFVTVKNNTMKYFKKMLLLHWRPS 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tmA_leucokinin-like	36..329	CDD:320515	80/298 (27%)
		TM helix 1	37..63	CDD:320515	7/25 (28%)
		TM helix 2	70..95	CDD:320515	11/24 (46%)
		TM helix 3	108..138	CDD:320515	12/29 (41%)
		TM helix 4	149..170	CDD:320515	7/20 (35%)
		TM helix 5	205..234	CDD:320515	7/30 (23%)
		TM helix 6	254..284	CDD:320515	7/29 (24%)
		TM helix 7	297..322	CDD:320515	6/24 (25%)
Prokr2	NP_620434.2	7tmA_prokineticin-R	92..382	CDD:320332	86/319 (27%)
		TM helix 1	93..119	CDD:320332	8/27 (30%)
		TM helix 2	126..151	CDD:320332	11/24 (46%)
		TM helix 3	166..196	CDD:320332	12/29 (41%)
		TM helix 4	207..228	CDD:320332	7/20 (35%)
		TM helix 5	258..287	CDD:320332	6/28 (21%)
		TM helix 6	306..336	CDD:320332	7/29 (24%)
		TM helix 7	350..375	CDD:320332	8/44 (18%)