DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and Prokr1

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_620433.1	Gene:	Prokr1 / 192648	RGDID:	708443	Length:	393	Species:	Rattus norvegicus

Alignment Length:	362	Identity:	92/362 - (25%)
Similarity:	180/362 - (49%)	Gaps:	25/362 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EEEAEFERLYAAPAEIVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVI 83
            ||:....|.:.|...::.:..:   ||.:|..|||.:.|..:|..:::|.:||:.|||||.:|.:
  Rat    49 EEDVTNSRTFFAAKIVIGMALV---GIMLVCGIGNFIFITALARYKKLRNLTNLLIANLAISDFL 110

  Fly    84 IGLFCIPFQFQAALLQ--SWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRARPT 146
            :.:.|.||:....:::  ||.....:|:...:::.:|:.||...|.||||||:.||::|||.|..
  Rat   111 VAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMK 175

  Fly   147 KFVSKFIIGGIWMLALLFAVPFAIAFRVEELTERFRENNETYNVTRPFCMNKNLSDDQL--QSFR 209
            ...:..:|..:|.:::|.|:|  .|:...|......|:.|     :.||......|.|.  :|:
  Rat   176 CQTAAGLIFLVWSVSILIAIP--AAYFTTETVLVIVESQE-----KIFCGQIWPVDQQFYYRSY- 232

  Fly   210 YTLVF-VQYLVPFCVISFVYIQMAVRLWGTRAPGNAQDSRDITLLKNKKKVIKMLIIVVIIFGLC 273
            :.||| ::::.|...::..|.:::..||....|| .|..:....|:.:::.:..|:.|:..:.||
  Rat   233 FLLVFGLEFVGPVIAMTLCYARVSRELWFKAVPG-FQTEQIRRRLRCRRRTVLGLVCVLSAYVLC 296

  Fly   274 WLPLQLYNILYVTIPE--INDYHFISIVWFCCDWLAMSNSCYNPFIY-GIYNEKFKREFNKRFAA 335
            |.|...:.|:....|.  :.:.|::: .::..:.:|||||..|...: .:.|...|  :.||...
  Rat   297 WAPFYGFTIVRDFFPSVFVKEKHYLT-AFYVVECIAMSNSMINTLCFVTVRNNTSK--YLKRILR 358

  Fly   336 CFCKFKTSMDAHERTFSMHTRASSIRSTYANSSMRIR 372
              .:::.|....:.:..:..|.:.|.:|.....:|::
  Rat   359 --LQWRASPSGSKASADLDLRTTGIPATEEVDCIRLK 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	79/290 (27%)
		7tm_1	52..318	CDD:278431	75/272 (28%)
		PHA03216	467..>519	CDD:177558
Prokr1	NP_620433.1	7tmA_prokineticin-R	63..353	CDD:320332	81/304 (27%)
		TM helix 1	65..89	CDD:320332	7/26 (27%)
		TM helix 2	98..120	CDD:320332	10/21 (48%)
		TM helix 3	138..160	CDD:320332	6/21 (29%)
		TM helix 4	181..197	CDD:320332	5/17 (29%)
		TM helix 5	230..253	CDD:320332	5/23 (22%)
		TM helix 6	283..305	CDD:320332	6/21 (29%)
		TM helix 7	321..346	CDD:320332	6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	3	2.870