Protein Alignment Lkr and tkr-1

DIOPT Version :10

• Sequence 1: NP_647968.3
• Gene: Lkr / 38622
• FlyBaseID: FBgn0035610
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_499064.2
• Gene: tkr-1 / 192055
• WormBaseID: WBGene00006576
• Length: 406
• Species: Caenorhabditis elegans
• Alignment Length: 389
• Identity: 115/389 - (29%)
• Similarity: 190/389 - (48%)
• Gaps: 62/389 - (15%)

  Fly    15 LPGAEEEAEFERLYAAPAEIVALLSIFYGGISIV-----AVIGNTLVIWVVATTRQMRTVTNMYI 74
            || ||.|..|   :.||:...:|.:..:..|:.|     |:|||::|:|::...:.|....|.::
 Worm    22 LP-AELEGIF---FCAPSSRESLATQVFVAIAFVLLMATAIIGNSVVMWIIYQHKVMHYGFNYFL 82

  Fly    75 ANLAFADVIIGLFCIPFQFQAALLQSWNLPWF--MCSFCPFVQALSVNVSVFTLTAIAIDRHRAI 137
            .|:||||::|.||.:...:...|...|   |:  :|:...|.......|||.::.|::.||.:|:
 Worm    83 FNMAFADLLIALFNVGTSWTYNLYYDW---WYGDLCTLTSFFGIAPTTVSVCSMMALSWDRCQAV 144

  Fly   138 INPLRARP---TKFVSKFIIGGIWMLALLFAVPFAIAFRVEELTERFRENNETYNVTRPFCMNKN 199
            :|||:.||   .:.|...:|  ||:::.:.|:|||||..|..|        .||:|........:
 Worm   145 VNPLQKRPLSRKRSVIAILI--IWVVSTVTALPFAIAASVNSL--------YTYDVVTSTVSKAH 199

  Fly   200 LSDDQLQSFRYTLVF-VQYLVPFCVISFVYIQMAVRLWGTRAPGNAQDSRDITLLKN-----KKK 258
            :....:.:|...::| :||.:|..::...:.::||..   ||...|.||.    |||     |.|
 Worm   200 VCSAPVNTFFEKVLFGIQYALPIIILGSTFTRIAVAF---RATNEATDSS----LKNNHTRAKSK 257

  Fly   259 VIKMLIIVVIIFGLCWLPLQLYNILYVTIPEIND-----YHFISIVWFCCDWLAMSNSCYNPFIY 318
            .:|||.::|:.|.:||||..:|:..  .:.|..|     |.::.|.     |:|||:..|||.||
 Worm   258 AVKMLFLMVVAFVVCWLPYHIYHAF--ALEEFFDAARGKYAYLLIY-----WIAMSSCAYNPIIY 315

  Fly   319 GIYNEKFKREFNKRF---AACFCKFKTSMDAHERTF--SMHTRASSIRSTYANSS---MRIRSN 374
            ...||:|:..|...|   ....|| |...: :.:.|  .|.:.|.|::....|||   .:::.|
 Worm   316 CFANERFRIGFRYVFRWIPVIDCK-KEQYE-YSQLFPDKMRSMAISLQKGRVNSSCLDKKVKEN 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tmA_leucokinin-like	36..329	CDD:320515	94/313 (30%)
		TM helix 1	37..63	CDD:320515	9/30 (30%)
		TM helix 2	70..95	CDD:320515	9/24 (38%)
		TM helix 3	108..138	CDD:320515	9/29 (31%)
		TM helix 4	149..170	CDD:320515	7/20 (35%)
		TM helix 5	205..234	CDD:320515	6/29 (21%)
		TM helix 6	254..284	CDD:320515	14/34 (41%)
		TM helix 7	297..322	CDD:320515	10/24 (42%)
tkr-1	NP_499064.2	7tm_GPCRs	44..326	CDD:475119	93/308 (30%)
		TM helix 1	46..70	CDD:320512	8/23 (35%)
		TM helix 2	79..101	CDD:320512	9/21 (43%)
		TM helix 3	116..138	CDD:320512	5/21 (24%)
		TM helix 4	160..176	CDD:320512	4/17 (24%)
		TM helix 5	207..230	CDD:320512	5/22 (23%)
		TM helix 6	259..281	CDD:320512	10/21 (48%)
		TM helix 7	294..319	CDD:320512	11/29 (38%)