DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and npr-9

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001361821.1	Gene:	npr-9 / 191320	WormBaseID:	WBGene00013974	Length:	431	Species:	Caenorhabditis elegans

Alignment Length:	424	Identity:	109/424 - (25%)
Similarity:	187/424 - (44%)	Gaps:	87/424 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EEEAEFERLY----AAPAEIVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAF 79
            ||..:.:::|    :...:|..::...:..|.:|.::||.||: :||..||||..||..|..||.
Worm     9 EEMEQLQKIYDDTISFERKIGIIIPTIFAVIILVGLVGNALVV-IVAFGRQMRNSTNTLIIGLAI 72

  Fly    80 ADVIIGLFCIPFQFQAALLQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRAR 144
            :|::..|.|:||........:|..|.:.||...|.|..|...||:|||.:|:||:.|::.|:.:.
Worm    73 SDLMFLLLCVPFTAVDYAAPTWIFPEWTCSMINFFQHTSAYCSVWTLTLMALDRYLAVVYPVESM 137

  Fly   145 PTKFVSKFIIG--GIWMLALLFAVP-------FAIAFRVEE------LTERFRENNETYNVTRPF 194
            ..:.....:|.  .|:::.:...:|       :...|.:|:      ||....|...|  :.|.:
Worm   138 TLRTPRNTVIALCFIYIIIIASQIPVGRMHGIYVYDFIMEKRSTCAILTIATAEATPT--MARTY 200

  Fly   195 CMNKNLSDDQLQSFRYTLVFVQYLVPFCVISFVYIQMAVRLWGTRAPGNAQD--SRDIT------ 251
            .|..|             || .|::|..:...:|..|..:||....|||:|.  .|::|
Worm   201 FMTFN-------------VF-GYVLPLGISVVLYGLMLRKLWDMPRPGNSQSVGGRNLTNRDSGS 251

  Fly   252 -------LLKNKKKVIKMLIIVVIIFGLCWLPLQLYNILY----VTIPE---INDYHFISIVWFC 302
                   ....|:||.::::.|:|.:.||||||   |:.:    :..||   |:....:.||...
Worm   252 SIRRRPEATAAKRKVTRLVLCVLITWALCWLPL---NVCFFMSGLAYPEPLVISHGVIMVIVQIA 313

  Fly   303 CDWLAMSNSCYNPFIYGIYNEKFKREF--------NKRFAACFC------KFKTSMDAHERT--- 350
            ...||.:|||.||.:|.:.::.|:..|        ||.....||      ..:|.:..:.:|
Worm   314 SQVLAYTNSCLNPILYALMSQSFREGFIRVMKMLINKLSRGRFCTNYRRSALRTELTHYNQTPAH 378

  Fly   351 -------FSMHTRASSIR--STYANSSMRIRSNL 375
                   .|...|:|.::  |:.|.|...:|:::
Worm   379 PANTVVQVSNGERSSLLKDNSSSATSVQPLRTSI 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	90/319 (28%)
		7tm_1	52..318	CDD:278431	87/302 (29%)
		PHA03216	467..>519	CDD:177558
npr-9	NP_001361821.1	7tmA_AstA_R_insect	30..340	CDD:320224	91/329 (28%)
		TM helix 1	32..56	CDD:320224	8/24 (33%)
		TM helix 2	64..86	CDD:320224	9/21 (43%)
		TM helix 3	102..124	CDD:320224	9/21 (43%)
		TM helix 4	147..163	CDD:320224	2/15 (13%)
		TM helix 5	198..221	CDD:320224	7/36 (19%)
		TM helix 6	267..289	CDD:320224	9/24 (38%)
		TM helix 7	308..333	CDD:320224	10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910