Protein Alignment Lkr and npr-6

DIOPT Version :10

• Sequence 1: NP_647968.3
• Gene: Lkr / 38622
• FlyBaseID: FBgn0035610
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_509725.2
• Gene: npr-6 / 185623
• WormBaseID: WBGene00009619
• Length: 402
• Species: Caenorhabditis elegans
• Alignment Length: 362
• Identity: 100/362 - (27%)
• Similarity: 178/362 - (49%)
• Gaps: 53/362 - (14%)

  Fly     1 MAMDLIEQESRL--EFLPGAEEEAEFERLYAAPAEIVALLSIF---YGGISIVAVIGNTLVIWVV 60
            |:.||:...|.:  |..|..:...:.:.   .|.|:......|   |..:.:||..||.||::||
 Worm     1 MSNDLVPSVSSILNETTPSYQSTCKIKN---NPMEMEYFRPFFISMYCAVFLVASSGNFLVVYVV 62

  Fly    61 ATTRQMRTVTNMYIANLAFADVIIGLFCIPFQFQAALLQSWNLPWFMCSFCPFVQALSVNVSVFT 125
            .|.::|:|:||::|.|||.:|:::....:........:..|.....:|...|..|..|:.:|.:|
 Worm    63 MTNKRMQTITNIFITNLAVSDIMVNFTSLWLTPTYTSIGHWIFGGGLCHGLPLFQGTSIFISTWT 127

  Fly   126 LTAIAIDRHRAI------INPLRARPTKFVSKFIIGGIWMLALLFAVPFAIAFRVEELTERFREN 184
            ||||||||:..|      ||.......:....||: .||:.:||...|:||..::..:.|
 Worm   128 LTAIAIDRYIVIVHNSSNININDRMSMRSCLSFIV-LIWLCSLLLVTPYAINMKLNYIHE----- 186

  Fly   185 NETYNVTRP----FCMNKNLSDDQLQS-FRYTLVFVQYLVPFCVISFVYIQMAVRLWGTRAPGNA 244
                    |    .| :::.|:.:.:| |...::.:|:::||.:|:..||::.:.|       |:
 Worm   187 --------PCDFLIC-SEDWSNAEFRSIFGIVVMILQFILPFVLIAISYIKIWLFL-------NS 235

  Fly   245 QDS-----RDITLLKNKKKVIKMLIIVVIIFGLCWLPLQLYNILYVTIPEINDY--HFISIVWFC 302
            :.|     .||   |.||::::|||::|:||.:||.|..|.|.|...  :::::  .:.|.|:..
 Worm   236 RQSMTERKSDI---KRKKRLLRMLIVMVVIFAICWFPFNLLNCLRDL--KLDNFMRGYFSFVFLS 295

  Fly   303 CDWLAMSNSCYNPFIYGIYNEKFKREFNKRFAACFCK 339
            ...::|:.:.:||.:|...||.|:.||.|.....|.:
 Worm   296 VHLMSMTATAWNPILYAFMNETFREEFAKVVPCLFAR 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tmA_leucokinin-like	36..329	CDD:320515	88/313 (28%)
		TM helix 1	37..63	CDD:320515	10/28 (36%)
		TM helix 2	70..95	CDD:320515	7/24 (29%)
		TM helix 3	108..138	CDD:320515	15/35 (43%)
		TM helix 4	149..170	CDD:320515	7/20 (35%)
		TM helix 5	205..234	CDD:320515	8/29 (28%)
		TM helix 6	254..284	CDD:320515	14/29 (48%)
		TM helix 7	297..322	CDD:320515	6/24 (25%)
npr-6	NP_509725.2	7tmA_NPYR-like	39..322	CDD:320331	88/309 (28%)
		TM helix 1	39..65	CDD:320331	10/25 (40%)
		TM helix 2	72..97	CDD:320331	7/24 (29%)
		TM helix 3	110..140	CDD:320331	14/29 (48%)
		TM helix 4	156..177	CDD:320331	7/21 (33%)
		TM helix 5	203..232	CDD:320331	8/28 (29%)
		TM helix 6	247..277	CDD:320331	14/29 (48%)
		TM helix 7	290..315	CDD:320331	6/24 (25%)