DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and npr-4

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001300304.1	Gene:	npr-4 / 182684	WormBaseID:	WBGene00007635	Length:	490	Species:	Caenorhabditis elegans

Alignment Length:	479	Identity:	107/479 - (22%)
Similarity:	193/479 - (40%)	Gaps:	100/479 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVIIGLFCIPFQFQAALL 98
            |:.:.:..|..|....:|||:.||..:...:.::||.|::|.:|:.:|:::...........|..
Worm    48 IMLVFAFLYLIIIAAGIIGNSCVILAITRNKSLQTVPNLFILSLSCSDIVVCCTSATITPITAFK 112

  Fly    99 QSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRARPTKFVSKFIIGGIWMLALL 163
            :.|.....:|...||:..:|:..|.||||||:|||:..|..|:|...|.:.:..:|..|...|..
Worm   113 KEWIFGEALCRIAPFIAGISLCFSTFTLTAISIDRYILIRFPMRKPITHYQAVGVIAIICAFAAT 177

  Fly   164 FAVPFAIAFRVEELTERFRENNETYNVTRPFCM-NKNLSDDQLQSFRYTLVFVQYLVPFCVISFV 227
            ...|  |.|:        ::..|..|....:|. |...::.|.:.:...|:|:|.::|..:|...
Worm   178 ITSP--IMFK--------QKLGEFENFCGQYCTENWGANESQRKIYGAALMFLQLVIPLTIIIIS 232

  Fly   228 YIQMAVRLWGTR----APGNAQDSRDITL-------LKNKKKVIKMLIIVVIIFGLCWLPLQLYN 281
            |..:::::..:.    |.....|:.::.|       :|.:::..:|||.:|:.|...|:....:|
Worm   233 YTAISLKIGQSMILKGAKKQKTDNWEMELSDQQRIAVKRRQRTNRMLIGMVVAFACSWIWSVTFN 297

  Fly   282 IL--YVTIPEI---NDYHFISIVWFCCDWLAMSNSCYNPFIYGIYNEKFKREFNKRFAACFCKFK 341
            ||  |..:||:   .:|.| .|...|   :||:::.:||.:|.:.|.:.:..|
Worm   298 ILRDYEYLPELIKTQEYIF-GIATHC---IAMTSTVWNPLLYAVLNLQLRAAF------------ 346

  Fly   342 TSMDAHERTFSMHTRASSIRSTYANSSMRIRSNLFGPARGGVNNGKPGLHMPRV-----HGSGAN 401
              :|........|.                  ||.|      :|..|.|:.|.:     :||.|.
Worm   347 --IDLMPHWLRRHL------------------NLEG------DNSSPLLNHPTMTITNKYGSTAT 385

  Fly   402 SGIYNGSSGQNNNVNGQHHQHQSVVTFAATPGVSAPGVGVAMPPWRRNNF------KPLHPNVI- 459
            ..:   .:...|..|||             |.||...||...|......|      |.....::
Worm   386 KTV---KATYINTSNGQ-------------PYVSTSLVGKVQPEAPSFKFNGSGRKKSAMMRILV 434

  Fly   460 ---ECEDDVALMELPSTTPPSEEL 480
               ..|::..|:...|.:||..::
Worm   435 QKRNAEEEEQLITKESPSPPEIQM 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	74/299 (25%)
		7tm_1	52..318	CDD:278431	71/282 (25%)
		PHA03216	467..>519	CDD:177558	4/14 (29%)
npr-4	NP_001300304.1	TM helix 1	52..76	CDD:320331	7/23 (30%)
		TM helix 2	85..107	CDD:320331	4/21 (19%)
		TM helix 3	123..145	CDD:320331	10/21 (48%)
		TM helix 4	166..182	CDD:320331	4/17 (24%)
		TM helix 5	211..234	CDD:320331	5/22 (23%)
		TM helix 6	273..298	CDD:320331	6/24 (25%)
		TM helix 7	314..339	CDD:320331	9/28 (32%)
		7tmA_NPYR-like	50..346	CDD:320331	76/309 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910