Protein Alignment Lkr and npr-3

DIOPT Version :10

• Sequence 1: NP_647968.3
• Gene: Lkr / 38622
• FlyBaseID: FBgn0035610
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_502162.1
• Gene: npr-3 / 182494
• WormBaseID: WBGene00007006
• Length: 376
• Species: Caenorhabditis elegans
• Alignment Length: 354
• Identity: 92/354 - (25%)
• Similarity: 166/354 - (46%)
• Gaps: 41/354 - (11%)

  Fly    33 EIVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVIIGLFCIPFQFQAAL 97
            :|.|:.|:.|..:.:.|::|||||::|:...:...:|..:::..||.:|:::.||.:|....:..
 Worm    23 QIRAIFSLLYLLVWVGAIVGNTLVLYVLTFNQVSLSVRTVFVGCLAGSDLLMCLFSLPITAISIF 87

  Fly    98 LQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDR-------HRAIINPLRARPTKFVSKFIIG 155
            .:.|..|...|......|..::.||.||||.||:||       ::.|:|..||       .||:.
 Worm    88 SRVWVFPAIFCKLIGVFQGGTIFVSSFTLTVIALDRCVLILRPNQEIVNFPRA-------VFIVF 145

  Fly   156 GIWMLALLFAVPFAIAFRV---EELTERFRENN-ETYNVTRPFCMNKNLSDDQLQSFRYTLVFVQ 216
            .||:|....|:|..|...:   :|:...|.|.| ..:|   |......:.    :::..:::.:|
 Worm   146 CIWLLGYSLALPVGIYSDIAVYDEICGTFCEENWPDFN---PDTGRSGIR----RAYGLSVLVLQ 203

  Fly   217 YLVPFCVISFVYIQ----MAVRLWGTRAPGNAQDSRDITLLKNKKKVIKMLIIVVIIFGLCWLPL 277
            :.:|..:.|..|..    |:.:| ..|...|.:...:..|:..|.:..:|:|::|:.|.|.|:|.
 Worm   204 FGIPALISSICYWMISRVMSDQL-ARRRGHNIRPESETKLVNRKTRANRMMIVMVVGFVLAWMPF 267

  Fly   278 QLYNILYVTIPEINDYHFISIVWFCCDWLAMSNSCYNPFIYGIYNEKFKREFNKRF----AACFC 338
            ...| ||..:..|:.::  |.|:..|...||.::..||.||..:|.:|::.....|    .|...
 Worm   268 NAVN-LYRDLFGISKWY--STVFALCHVCAMCSAVLNPIIYSWFNPQFRQSITTLFKGTDEARLI 329

  Fly   339 KFK----TSMDAHERTFSMHTRASSIRST 363
            |.|    :.|.::...||...:.:.|.||
 Worm   330 KKKPQSTSKMVSYPTNFSEIRKETEIAST 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tmA_leucokinin-like	36..329	CDD:320515	81/307 (26%)
		TM helix 1	37..63	CDD:320515	9/25 (36%)
		TM helix 2	70..95	CDD:320515	6/24 (25%)
		TM helix 3	108..138	CDD:320515	12/36 (33%)
		TM helix 4	149..170	CDD:320515	7/20 (35%)
		TM helix 5	205..234	CDD:320515	5/32 (16%)
		TM helix 6	254..284	CDD:320515	9/29 (31%)
		TM helix 7	297..322	CDD:320515	9/24 (38%)
npr-3	NP_502162.1	7tmA_NPYR-like	26..314	CDD:320331	81/305 (27%)
		TM helix 1	27..53	CDD:320331	9/25 (36%)
		TM helix 2	60..85	CDD:320331	6/24 (25%)
		TM helix 3	98..128	CDD:320331	12/29 (41%)
		TM helix 4	139..160	CDD:320331	9/27 (33%)
		TM helix 5	192..221	CDD:320331	4/32 (13%)
		TM helix 6	244..274	CDD:320331	10/30 (33%)
		TM helix 7	284..309	CDD:320331	9/24 (38%)