DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and Npy2r

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_032757.2	Gene:	Npy2r / 18167	MGIID:	108418	Length:	381	Species:	Mus musculus

Alignment Length:	359	Identity:	108/359 - (30%)
Similarity:	177/359 - (49%)	Gaps:	55/359 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 EIVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVIIGLFCIPFQFQAAL 97
            |:..:|.:.|..|.::.|:||:|||.||...:.||||||.:|||||.||:::...|:||.....|
Mouse    48 EVQVILILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTL 112

  Fly    98 LQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRARPTKFVSKFIIGGIWMLAL 162
            :..|.:...:|...|:.|.|:|.||..|||.||:||||.|:..|.::.:|.:|..|||..|.::.
Mouse   113 MGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISA 177

  Fly   163 LFAVPFAI-----------AFRVEELTERF-RENNETYNVTRPFCMNKNLSDDQLQSFRYTLVFV 215
            |.|.|.||           .|.:...||:: .|....|...                :..:.:.:
Mouse   178 LLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSVYGTV----------------YSLSTLLI 226

  Fly   216 QYLVPFCVISFVYIQMAVRLWGTRAPGNAQDSRDITLLKNKKKVIKMLIIVVIIFGLCWLPLQLY 280
            .|::|..:|||.|.::..:|....:||.|.|...    :.:.|:.|||:.||::|.:.||||..:
Mouse   227 LYVLPLGIISFSYTRIWSKLRNHVSPGAASDHYH----QRRHKMTKMLVCVVVVFAVSWLPLHAF 287

  Fly   281 NILYVTIP----EINDYHFISIVWFCCDWLAMSNSCYNPFIYGIYNEKFKREFNKRFAACFCKFK 341
            . |.|.|.    ::.:|..|..|:..   :||.::..||.:||..|..:::.|...|.   |:
Mouse   288 Q-LAVDIDSHVLDLKEYKLIFTVFHI---IAMCSTFANPLLYGWMNSNYRKAFLSAFR---CE-- 343

  Fly   342 TSMDAHERTFSMHTRASSIRSTY-ANSSMRIRSN 374
                  :|..::|   |.:..|: |..::.::.|
Mouse   344 ------QRLDAIH---SEVSMTFKAKKNLEVKKN 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	95/298 (32%)
		7tm_1	52..318	CDD:278431	91/281 (32%)
		PHA03216	467..>519	CDD:177558
Npy2r	NP_032757.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		7tmA_NPY2R	51..336	CDD:320521	98/308 (32%)
		TM helix 1	52..78	CDD:320521	11/25 (44%)
		TM helix 2	85..110	CDD:320521	12/24 (50%)
		TM helix 3	123..153	CDD:320521	16/29 (55%)
		TM helix 4	164..185	CDD:320521	8/20 (40%)
		TM helix 5	216..245	CDD:320521	6/44 (14%)
		TM helix 6	261..291	CDD:320521	12/30 (40%)
		TM helix 7	304..329	CDD:320521	8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910