DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and Npy1r

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001345884.1	Gene:	Npy1r / 18166	MGIID:	104963	Length:	382	Species:	Mus musculus

Alignment Length:	348	Identity:	112/348 - (32%)
Similarity:	183/348 - (52%)	Gaps:	36/348 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PAEIVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVIIGLFCIPFQFQA 95
            |..::..|::.||.:.|:.|.||..:|.::...::||.|||:.|.||:|:|:::.:.|:||.|..
Mouse    35 PLAVIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAVMCLPFTFVY 99

  Fly    96 ALLQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRARPTKFVSKFIIGGIWML 160
            .|:..|.....||...||||.:|:.||:|:|..||::||:.||||...||....:...|..||:|
Mouse   100 TLMDHWVFGETMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYIGITVIWVL 164

  Fly   161 ALLFAVPFAIAFRVEELTERFREN------NETYNVTRPFCMNKNLSDDQLQSFRYTLVFVQYLV 219
            |:..::||.|   .:.||:...:|      .:.|     .|.:|..||....|:...|:.:||..
Mouse   165 AVASSLPFVI---YQILTDEPFQNVSLAAFKDKY-----VCFDKFPSDSHRLSYTTLLLVLQYFG 221

  Fly   220 PFCVISFVYIQMAVRLWGTRAPGNAQDS-RDITLLKNKKKVIK-MLIIVVIIFGLCWLPLQLYNI 282
            |.|.|...|.::.:||   :...|..|. ||.....::.|.|. ||:.:|:.|.:|||||.::|.
Mouse   222 PLCFIFICYFKIYIRL---KRRNNMMDKIRDSKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNT 283

  Fly   283 LYVTIPEINDY-HFI------SIVWFCCDWLAMSNSCYNPFIYGIYNEKFKREFNKRFAACFCKF 340
            ::       |: |.|      ::::..|...||.::|.||..||..|:.|:|:.  :|...||.|
Mouse   284 VF-------DWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDL--QFFFNFCDF 339

  Fly   341 KTSMDAHERTFSMHTRASSIRST 363
            ::..|.:| |.:|.|..:.:..|
Mouse   340 RSRDDDYE-TIAMSTMHTDVSKT 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	98/297 (33%)
		7tm_1	52..318	CDD:278431	91/280 (33%)
		PHA03216	467..>519	CDD:177558
Npy1r	NP_001345884.1	7tmA_NPY1R	40..330	CDD:320517	101/307 (33%)
		TM helix 1	42..66	CDD:320517	8/23 (35%)
		TM helix 2	75..97	CDD:320517	9/21 (43%)
		TM helix 3	113..135	CDD:320517	10/21 (48%)
		TM helix 4	156..172	CDD:320517	5/15 (33%)
		TM helix 5	208..231	CDD:320517	7/22 (32%)
		TM helix 6	261..283	CDD:320517	9/21 (43%)
		TM helix 7	298..323	CDD:320517	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5959
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860