DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and Grpr

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_032203.1	Gene:	Grpr / 14829	MGIID:	95836	Length:	384	Species:	Mus musculus

Alignment Length:	374	Identity:	104/374 - (27%)
Similarity:	178/374 - (47%)	Gaps:	64/374 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FLPGAEEEAEFERLYAAPAEIVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLA 78
            |.||.        :|..||        .||.|.::.:|||..:|.:..|.:.||.|.|::|::||
Mouse    36 FHPGF--------IYVIPA--------VYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLA 84

  Fly    79 FADVIIGLFCIPFQFQAALLQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRA 143
            ..|:::.:.|.|......|...|......|...||:|..||.||||||||::.||::||:.|:..
Mouse    85 LGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDI 149

  Fly   144 RPTKFVSKFIIGG--IWMLALLFAVPFAI-----AFRVEELTERFRENNETYNVTRPFCMNKNLS 201
            :.:..:.|..:..  ||::::|.|:|.|:     .|.|       ::.|:|:....|: .:.|..
Mouse   150 QASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPFHV-------KDTNQTFISCAPY-PHSNEL 206

  Fly   202 DDQLQSFRYTLVFVQYLVPFCVISFVYIQMAVRL----WGTRAPGNAQDSRDITLLKNKKKVIKM 262
            ..::.|....|||  |::|..:||..|..:|..|    :.....||....:.|   :::|::.|.
Mouse   207 HPKIHSMASFLVF--YVIPLAIISVYYYFIARNLIQSAYNLPVEGNIHVKKQI---ESRKRLAKT 266

  Fly   263 LIIVVIIFGLCWLP---LQLYNILYVTIPEINDYHFISIVWFCCDWLAMSNSCYNPFIYGIYNEK 324
            :::.|.:|..||||   :.||...:.:..:.:..||::.:  |...||.:|||.|||...:.::.
Mouse   267 VLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSI--CARLLAFTNSCVNPFALYLLSKS 329

  Fly   325 FKREFNK-----------------RFAACFCKFKTSMDAHERTFSMHTR 356
            |:::||.                 |...|...||::..:  .|||:..|
Mouse   330 FRKQFNTQLLCCQPGLMNRSHSTGRSTTCMTSFKSTNPS--ATFSLINR 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	85/296 (29%)
		7tm_1	52..318	CDD:278431	83/279 (30%)
		PHA03216	467..>519	CDD:177558
Grpr	NP_032203.1	7tm_1	58..321	CDD:278431	81/277 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910