DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lkr and Brs3

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_033896.2	Gene:	Brs3 / 12209	MGIID:	1100501	Length:	399	Species:	Mus musculus

Alignment Length:	364	Identity:	115/364 - (31%)
Similarity:	184/364 - (50%)	Gaps:	41/364 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IVALLSIF--YGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVIIGLFCIPFQFQAA 96
            |.||.:|:  |.||..|.::||.::|.|...|:.|:||.|::|.:|||.|:::.|.|:|......
Mouse    44 IEALCAIYITYAGIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHY 108

  Fly    97 LLQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRARPTKFVSKFI--IGGIWM 159
            |.:.|......|....|::..||.|||||||.::.||::|::.||..:|...:.|..  .||||:
Mouse   109 LAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPPNAILKTCAKAGGIWI 173

  Fly   160 LALLFAVPFAIAFRVEELTERFRENNETYNVTRPFCMNKNLSDDQLQSFRYTLVF-VQYLVPFCV 223
            ::::||:|.||...|    ..|::.|.  |||...|.:..:|:..||.....|.| |.|::|..:
Mouse   174 VSMIFALPEAIFSNV----YTFQDPNR--NVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSI 232

  Fly   224 ISFVYIQMAVRLW-GTRAPGNAQDSRDITLLKNKKKVIKMLIIVVIIFGLCWLP---LQLY-NIL 283
            ||..|..:|..|: .|......:.|.....::::|::.|.::::|.:|.|||||   |.|| :..
Mouse   233 ISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFT 297

  Fly   284 YVTIPEINDYHFISIVWFCCDWLAMSNSCYNPF-IYGIYNEKFKREFNKRFAACFCKFK------ 341
            |.:....:|..|:.|::  ...||.||||.||| :|.:     .:.|.:.|.|..|..|
Mouse   298 YESYANHSDVPFVIIIF--SRVLAFSNSCVNPFALYWL-----SKTFQQHFKAQLCCLKAEQPEP 355

  Fly   342 ----------TSMDAHERTFSMHTRASSIRSTYANSSMR 370
                      |.|.....|.|.|....|: :.::.||.:
Mouse   356 PLGDIPLNNLTVMGRVPATGSAHVSEISV-TLFSGSSAK 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	95/291 (33%)
		7tm_1	52..318	CDD:278431	93/274 (34%)
		PHA03216	467..>519	CDD:177558
Brs3	NP_033896.2	7tm_1	64..328	CDD:278431	91/271 (34%)
Brs3	NP_033896.2	7tm_4	<137..347	CDD:304433	70/222 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910