DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lkr and GPR83

DIOPT Version :9

Sequence 1:NP_647968.3 Gene:Lkr / 38622 FlyBaseID:FBgn0035610 Length:542 Species:Drosophila melanogaster
Sequence 2:NP_057624.3 Gene:GPR83 / 10888 HGNCID:4523 Length:423 Species:Homo sapiens


Alignment Length:321 Identity:107/321 - (33%)
Similarity:167/321 - (52%) Gaps:26/321 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 RLYAAPAE---IVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVIIGLF 87
            |.|.|.::   :.|||.:.|..|.:.::.||.||..|:...::|.:.|:::|.|||.||::|.|.
Human    59 RRYGAESQNPTVKALLIVAYSFIIVFSLFGNVLVCHVIFKNQRMHSATSLFIVNLAVADIMITLL 123

  Fly    88 CIPFQFQAALLQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRARPTKFVSKF 152
            ..||.....:..:|.....||....|.|..|::||..||||||:|||:.|::||:.|.:......
Human   124 NTPFTLVRFVNSTWIFGKGMCHVSRFAQYCSLHVSALTLTAIAVDRHQVIMHPLKPRISITKGVI 188

  Fly   153 IIGGIWMLALLFAVPFAIAFRVEELTERFRENNETYNVTRPFCMNKNLSD-----DQLQSFRYTL 212
            .|..||.:|..|::|.||..::  .|.::.|     ::.|..|    |.|     |....:....
Human   189 YIAVIWTMATFFSLPHAICQKL--FTFKYSE-----DIVRSLC----LPDFPEPADLFWKYLDLA 242

  Fly   213 VFV-QYLVPFCVISFVYIQMAVRLWGTRAPGNAQDSRDITLLKNKKKVIKMLIIVVIIFGLCWLP 276
            .|: .|::|..:||..|.::|.:||.....|:....:...|.:.|||.||||::||::|.|||.|
Human   243 TFILLYILPLLIISVAYARVAKKLWLCNMIGDVTTEQYFALRRKKKKTIKMLMLVVVLFALCWFP 307

  Fly   277 LQLYNILYVT-IPEINDYHFISIVWFCCDWLAMSNSCYNPFIYGIYNEKFKREFNKRFAAC 336
            |..|.:|..: :...|     :.::|...|.|||::|||||||...||.|:.|.....:.|
Human   308 LNCYVLLLSSKVIRTN-----NALYFAFHWFAMSSTCYNPFIYCWLNENFRIELKALLSMC 363

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LkrNP_647968.3 7tm_4 46..329 CDD:304433 97/289 (34%)
7tm_1 52..318 CDD:278431 92/272 (34%)
PHA03216 467..>519 CDD:177558
GPR83NP_057624.3 7tmA_GPR83 72..356 CDD:320511 102/299 (34%)
TM helix 1 73..99 CDD:320511 9/25 (36%)
TM helix 2 106..131 CDD:320511 11/24 (46%)
TM helix 3 144..174 CDD:320511 15/29 (52%)
TM helix 4 185..206 CDD:320511 6/20 (30%)
TM helix 5 236..265 CDD:320511 7/28 (25%)
TM helix 6 285..315 CDD:320511 16/29 (55%)
TM helix 7 324..349 CDD:320511 12/24 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 402..423
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1254727at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X257
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.920

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