DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and PROKR1

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_620414.1	Gene:	PROKR1 / 10887	HGNCID:	4524	Length:	393	Species:	Homo sapiens

Alignment Length:	345	Identity:	89/345 - (25%)
Similarity:	171/345 - (49%)	Gaps:	22/345 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EEEAEFERLYAAPAEIVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVI 83
            :|:....|.:.|...::.:..:   ||.:|..|||.:.|..:...:::|.:||:.|||||.:|.:
Human    49 DEDVTNSRTFFAAKIVIGMALV---GIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFL 110

  Fly    84 IGLFCIPFQFQAALLQ--SWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRARPT 146
            :.:.|.||:....:::  ||.....:|:...:::.:|:.||...|.||||||:.||::|||.|..
Human   111 VAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMK 175

  Fly   147 KFVSKFIIGGIWMLALLFAVPFAIAFRVEELTERFRENNETYNVTRPFCMNKNLSDDQLQSFRYT 211
            ...:..:|..:|.:::|.|:|.|. |..|.:....:...:.      ||......|.||....|.
Human   176 CQTATGLIALVWTVSILIAIPSAY-FTTETVLVIVKSQEKI------FCGQIWPVDQQLYYKSYF 233

  Fly   212 L-VF-VQYLVPFCVISFVYIQMAVRLWGTRAPGNAQDSRDITLLKNKKKVIKMLIIVVIIFGLCW 274
            | :| ::::.|...::..|.:::..||....|| .|..:....|:.::|.:.:|:.::..:.|||
Human   234 LFIFGIEFVGPVVTMTLCYARISRELWFKAVPG-FQTEQIRKRLRCRRKTVLVLMCILTAYVLCW 297

  Fly   275 LPLQLYNILYVTIPE--INDYHFISIVWFCCDWLAMSNSCYNPFIY-GIYNEK---FKREFNKRF 333
            .|...:.|:....|.  :.:.|::: .::..:.:|||||..|...: .:.|:.   ||:.....:
Human   298 APFYGFTIVRDFFPTVFVKEKHYLT-AFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHW 361

  Fly   334 AACFCKFKTSMDAHERTFSM 353
            .|.:...|:|.|...:|..|
Human   362 KASYNGGKSSADLDLKTIGM 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	78/292 (27%)
		7tm_1	52..318	CDD:278431	73/271 (27%)
		PHA03216	467..>519	CDD:177558
PROKR1	NP_620414.1	7tmA_prokineticin-R	63..353	CDD:320332	78/301 (26%)
		TM helix 1	64..90	CDD:320332	7/28 (25%)
		TM helix 2	97..122	CDD:320332	11/24 (46%)
		TM helix 3	137..167	CDD:320332	12/29 (41%)
		TM helix 4	178..199	CDD:320332	5/20 (25%)
		TM helix 5	229..258	CDD:320332	5/28 (18%)
		TM helix 6	277..307	CDD:320332	7/29 (24%)
		TM helix 7	321..346	CDD:320332	6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870