DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and XB982628

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	XP_002933014.2	Gene:	XB982628 / 100493271	XenbaseID:	XB-GENE-982629	Length:	387	Species:	Xenopus tropicalis

Alignment Length:	344	Identity:	114/344 - (33%)
Similarity:	191/344 - (55%)	Gaps:	34/344 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RLEFLPGAEEEAEFERLY---------AAPAEIVALLSIF-------YGGISIVAVIGNTLVIWV 59
            ::|...|...|.|...:|         :||...|.|:..:       |..:.::.:.||.|:::|
Frog    38 KMETTIGWSYEPENLTIYMVNKNGSNASAPFTGVQLIQSYKPLFIPCYTLVVLIGIFGNYLLLYV 102

  Fly    60 VATTRQMRTVTNMYIANLAFADVIIGLFCIPFQFQAAL-LQSWNLPWFMCSFCPFVQALSVNVSV 123
            :..||:|..|||.:|.||||:|:::...|:||....|. .|.|....|||.|...:|.::|.|||
Frog   103 ICRTRKMHNVTNFFIGNLAFSDMLMCATCVPFTLAYAFNPQGWVFGKFMCYFVFLMQPVTVYVSV 167

  Fly   124 FTLTAIAIDRHRAIINPLRARPTKFVSKFIIGGIWMLALLFAVPFAIA--FRVEELTERFRENNE 186
            |||||||:||:.|.::||:.|.:.....:::.|||:|:.....| |||  :.||     |::  |
Frog   168 FTLTAIAVDRYYATVHPLKKRISVTTCIYVLMGIWLLSCALVGP-AIAHTYHVE-----FQQ--E 224

  Fly   187 TYNVTRPFCMNKNLSDDQLQSFRYTLVFVQYLVPFCVISFVYIQMAVRLWGTRAPGN-AQDSRDI 250
            .:.:...|.|.|   :.:..::.|:.:.:.|::|...:|..||.:.|:|.....||: .|...:.
Frog   225 GFTICEEFWMGK---ETERLAYAYSTLIITYILPLSAVSLSYICITVKLKNRVVPGHPTQSQAEF 286

  Fly   251 TLLKNKKKVIKMLIIVVIIFGLCWLPLQLYNILY-VTIPEINDYHFISIVWFCCDWLAMSNSCYN 314
            ..|: |:|:.:::::||..||:||||:.::||:. :.|..||.::|:.|..| |.|.|||:||.|
Frog   287 DRLR-KRKIFRLIVLVVTAFGICWLPIHVFNIIRDIDINLINKHYFLHIQLF-CHWFAMSSSCCN 349

  Fly   315 PFIYGIYNEKFKREFNKRF 333
            ||:|...:::|:.|..|.|
Frog   350 PFLYAWLHDRFRSELRKMF 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	101/287 (35%)
		7tm_1	52..318	CDD:278431	99/270 (37%)
		PHA03216	467..>519	CDD:177558
XB982628	XP_002933014.2	7tmA_PrRP_R	79..364	CDD:320516	102/297 (34%)
		TM helix 1	80..106	CDD:320516	5/25 (20%)
		TM helix 2	113..138	CDD:320516	11/24 (46%)
		TM helix 3	152..182	CDD:320516	17/29 (59%)
		TM helix 4	193..214	CDD:320516	6/21 (29%)
		TM helix 5	240..269	CDD:320516	6/28 (21%)
		TM helix 6	289..319	CDD:320516	13/30 (43%)
		TM helix 7	332..357	CDD:320516	13/25 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	176	1.000	Domainoid score	I3550
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134634
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto102481
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910