DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and gpr83.2

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	XP_002939760.1	Gene:	gpr83.2 / 100486806	XenbaseID:	XB-GENE-993677	Length:	423	Species:	Xenopus tropicalis

Alignment Length:	363	Identity:	115/363 - (31%)
Similarity:	179/363 - (49%)	Gaps:	45/363 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ERLYAAPAE---IVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVIIGL 86
            ::.|.|.::   :.|||.:.|..|.:.::.||.||..||...::|.:.|:::|.|||.||::|.|
Frog    58 KKRYGAESQNPMVKALLIVAYSFIIVFSLFGNVLVCHVVIKNKRMHSATSLFIVNLAVADILITL 122

  Fly    87 FCIPFQFQAALLQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRARPTKFVSK 151
            ...||.....:..:|.....||....|.|..|::||..||||||:|||:.|::||:.|.:.....
Frog   123 LNTPFTLARFVNSTWMFGKGMCHVSRFAQYCSLHVSALTLTAIAVDRHQVIMHPLKPRISTVKGV 187

  Fly   152 FIIGGIWMLALLFAVPFAIAFRVEELTERFRENNETYNVTRPFCMNKNLSDDQLQSFRY----TL 212
            ..|..||::|..|::|.||..::  .|..:.|.|     .|..|: .:..:.....::|    |.
Frog   188 AYIAIIWIMATCFSLPHAIYQKL--FTFEYSEEN-----IRSLCL-PDFPEPSDLFWKYLDLATF 244

  Fly   213 VFVQYLVPFCVISFVYIQMAVRLWGTRAPGNAQDSRDITLLKNKKKVIKMLIIVVIIFGLCWLPL 277
            :.: |::|..:||..|..:|.:||...|.|:....:...|.:.|||.||||::||::|.:||.||
Frog   245 ILL-YVLPLLIISVAYTTVAKKLWLRNAIGDVTTEQYFALRRKKKKTIKMLMLVVVLFAVCWFPL 308

  Fly   278 QLYNILY--VTIPEINDYHFISIVWFCCDWLAMSNSCYNPFIYGIYNEKFKREFNKRFAACFCKF 340
            ..|.:|.  .||...|      .::|...|.|||::|||||||...|:.|:.|.  :.....||.
Frog   309 NCYVVLLSSQTIRTNN------ALYFAFHWFAMSSTCYNPFIYCWLNDNFRSEL--KALLNMCKK 365

  Fly   341 KTSMDAH-------------------ERTFSMHTRASS 359
            .|....|                   :|:...||..||
Frog   366 PTGPSEHMLPSSVPSYRVAWPENRSFKRSLVSHTLPSS 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	98/288 (34%)
		7tm_1	52..318	CDD:278431	94/271 (35%)
		PHA03216	467..>519	CDD:177558
gpr83.2	XP_002939760.1	7tmA_GPR83	72..356	CDD:320511	103/298 (35%)
		TM helix 1	73..99	CDD:320511	10/25 (40%)
		TM helix 2	106..131	CDD:320511	11/24 (46%)
		TM helix 3	144..174	CDD:320511	15/29 (52%)
		TM helix 4	185..206	CDD:320511	6/20 (30%)
		TM helix 5	236..265	CDD:320511	8/29 (28%)
		TM helix 6	285..315	CDD:320511	15/29 (52%)
		TM helix 7	324..349	CDD:320511	13/30 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1254727at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X257
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010