DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and tacr3

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	XP_002934808.1	Gene:	tacr3 / 100486525	XenbaseID:	XB-GENE-985728	Length:	431	Species:	Xenopus tropicalis

Alignment Length:	390	Identity:	124/390 - (31%)
Similarity:	206/390 - (52%)	Gaps:	25/390 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 YAAPAEIVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVIIGLFCIPFQ 92
            :..|...:||.|:.||.:..|||.||.:|||::...::||||||.::.||||:|..:..|.....
Frog    42 FVQPPWRIALWSLAYGSMVAVAVFGNIIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVN 106

  Fly    93 FQAALLQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRARPTKFVSKFIIGGI 157
            |..||...|......|.|..|....|:..|:::::|||:||:.|||:||:.|.:...:|.:||.|
Frog   107 FIYALHNEWYFGEAYCRFHNFFPITSIFASIYSMSAIAVDRYMAIIDPLKPRLSATSTKVVIGSI 171

  Fly   158 WMLALLFAVPFAIAFRVEELTERFRENNETYNVTRPFCMNKNLSDDQLQSFRYTLVFVQYLVPFC 222
            |:.|:|.|.|..:..:: .:|.           ||..||......|:..::::.||.:.|::|..
Frog   172 WIFAILLAFPQCLYSKI-RVTR-----------TRTLCMLVWPGKDERLTYQFILVLLVYVLPLI 224

  Fly   223 VISFVYIQMAVRLWGTRAPGNAQDSRDITLLKNKKKVIKMLIIVVIIFGLCWLPLQLYNILYVTI 287
            |:...|..:.:.|||...||:..|... ..|:.|:||:||:|:||:.|.:||||..::.:.....
Frog   225 VMGVTYTIVGITLWGGEIPGDTSDKYH-EQLRAKRKVVKMMIVVVVTFAICWLPYHIFFLADALD 288

  Fly   288 PEINDYHFISIVWFCCDWLAMSNSCYNPFIYGIYNEKFKREFNKRFAAC-FCKFKTSMDAHERTF 351
            .:::.:.:|..::....|||||::.|||.||...|::|:..|.:.|..| |.:..:..:...::.
Frog   289 IKLDRWKYIQQIYLAIFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIEVSSYDELELKST 353

  Fly   352 SMH-TRASSIRS-TYANSSMRIRSNLFGPARGGVNNGKPG-LHMPRVHGSGANSGIYNGSSGQNN 413
            ..| ||.||:.: :...|||.:   :|.|  ..|.|.||. .|..|   :..:...:||.|.:|:
Frog   354 RFHPTRQSSLYTVSRMESSMTV---VFDP--NDVENNKPSHSHKKR---AATSESTFNGCSRRNS 410

Fly 414 413
Frog 411 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	94/282 (33%)
		7tm_1	52..318	CDD:278431	87/265 (33%)
		PHA03216	467..>519	CDD:177558
tacr3	XP_002934808.1	7tm_4	58..>181	CDD:304433	48/122 (39%)
tacr3	XP_002934808.1	7tm_1	66..319	CDD:278431	87/265 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910