DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment blanks and ADAR

DIOPT Version :9

Sequence 1:	NP_647966.1	Gene:	blanks / 38620	FlyBaseID:	FBgn0035608	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_001351974.1	Gene:	ADAR / 103	HGNCID:	225	Length:	1235	Species:	Homo sapiens

Alignment Length:	324	Identity:	70/324 - (21%)
Similarity:	113/324 - (34%)	Gaps:	64/324 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IPNPSAEEDAVAVIPLADNLKKTAMGGENKSDEKGTVSSEPKALSDQITSSMRVTKNKIADDKSS 88
            ||..:|..:.|.. ...:|.::..:..||:.:.:    .||..|...:..: ..:|....|.::.
Human   403 IPTSNASNNMVTT-EKVENGQEPVIKLENRQEAR----PEPARLKPPVHYN-GPSKAGYVDFENG 461

  Fly    89 DVITDDA------------------------TNGRKKQKKNKKAKIRPLTMPVTSKDALMVLNEL 129
            ...|||.                        ::|..:....||.....|..|::   .|:...:.
Human   462 QWATDDIPDDLNSIRAAPGEFRAIMEMPSFYSHGLPRCSPYKKLTECQLKNPIS---GLLEYAQF 523

  Fly   130 KGVTVDNMQIKRD---HEGKIMARVVVNSKKY-EAEGSSVNSARNAACEKALQEILTTKMKAVLD 190
            ...|.:...|::.   ||.:...:||:|.::: .||..|...|:..|..||: .||..:.||  .
Human   524 ASQTCEFNMIEQSGPPHEPRFKFQVVINGREFPPAEAGSKKVAKQDAAMKAM-TILLEEAKA--K 585

  Fly   191 GPGKSLESDEDDILEKMASYAIHKLGEEWKTDDIDVATLYNDLKNKQTSVVEPKKPLPETWKNMH 255
            ..|||.||         :.|:..|  |..||.:....|      ...||....|.|:....:.||
Human   586 DSGKSEES---------SHYSTEK--ESEKTAESQTPT------PSATSFFSGKSPVTTLLECMH 633

  Fly   256 PCMVLNYMRPQCTFIVSGGTGTNQNNTFSMSVCVDNCEF-NAEGPSKKAARYKLSALVCNKLFG 318
            .      :...|.|.:....|......|...|.|....| :...||||.|:...:......|.|
Human   634 K------LGNSCEFRLLSKEGPAHEPKFQYCVAVGAQTFPSVSAPSKKVAKQMAAEEAMKALHG 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blanks	NP_647966.1	None
ADAR	NP_001351974.1	z-alpha	144..210	CDD:280459
		z-alpha	304..368	CDD:280459
		DSRM	513..578	CDD:214634	16/68 (24%)
		DSRM	624..689	CDD:214634	15/70 (21%)
		DSRM	736..801	CDD:214634
		ADEAMc	848..1231	CDD:214718
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158142
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930