DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4835 and C39D10.7

DIOPT Version :9

Sequence 1:	NP_647965.3	Gene:	CG4835 / 38619	FlyBaseID:	FBgn0035607	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	NP_509334.3	Gene:	C39D10.7 / 181050	WormBaseID:	WBGene00016534	Length:	1171	Species:	Caenorhabditis elegans

Alignment Length:	1235	Identity:	278/1235 - (22%)
Similarity:	410/1235 - (33%)	Gaps:	374/1235 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 EQRYENQVMCEGKDFGALVPYPDNCS---LFLVCDCLYPTVKLCPANLWWDNKTQQCNYPQAVEC 103
            :..:.:.|.|.        ||...||   ||.         |.||..|.:......|::|::|:
Worm   194 DMHFTDNVKCS--------PYFWQCSNGKLFR---------KTCPEKLIYVLDQNLCDFPESVK- 240

  Fly   104 IYYSIETPEPTDGTTRF-TPEPTSSTQ---KITPEPTEP----PSSTAKITTESTTGTSTEITSS 160
                 :.||.....|.: .|:.|:|:.   .|...|.:|    |:|....:...||......:::
Worm   241 -----DCPEYNGSETSYRAPKTTTSSSSYGSIAEAPVDPTPYAPASAPVYSPPRTTYVPRSTSAA 300

  Fly   161 TP---------SSYLPTSSWDPPPAP---------PGISDDYCRNKEDGSVHYYPYDCQA-YINC 206
            .|         :.|:||   :..|:|         |.:..| |:|: ||.  :...:|.| :::|
Worm   301 PPNPPPQNPTAAPYVPT---EATPSPVFSSTVRYNPAVHGD-CKNR-DGI--FGIKECHASFLSC 358

  Fly   207 TYGWPVLNYCIEDKVFNKYLGICDTPDMADCEELPLPTTTTEMPPTSTTEEDV--------VCGP 263
            ..|...:..|.::.||:..:..|:.  .|.|.|...|             |||        ....
Worm   359 DNGVGRVIQCADNLVFDTRVSACEF--AAICLEPRKP-------------EDVPVLYNHGGAYNE 408

  Fly   264 TPEGIEEDY-CVPKGNGFYEYPYNCSGYLACKNGCTDLDYCQPDKLFNNWLHICDTPDSVR---C 324
            .|..::.|: |..|.||.|........:..|.:|....:.|..|.:||.....||..::..   .
Worm   409 RPAEVKVDFDCTGKPNGKYIKEACTKSFFTCHDGRAFANDCPGDLVFNKATGTCDFAENCEKNYM 473

  Fly   325 DPLPF------PTTP---------GTTNKPTTPSVTTTPSITTTPST----------PTTLPSDG 364
            :|...      |||.         .||.:|.|...|..|..|..|||          |||:   |
Worm   474 EPSQIYKGEDTPTTTIGYSSSVVYTTTEQPATKPYTQPPRDTERPSTIYGRPIYTKAPTTV---G 535

  Fly   365 STTEIHSSTTEEIVTTTDGLPSDVDPNDCKDEKDGTIFAYIGNC-SEYLICKDNQVQMGHCPPNT 428
            ......:.||:..||||..|    |...||...||...:  |.| |.:.||.:.||....||.|.
Worm   536 YEQPKATYTTQAPVTTTIAL----DDFSCKHLADGNHAS--GLCKSVFYICANGQVVATTCPANL 594

  Fly   429 LFNPDLLVCDEPDDV-VCLGDRTTTPIPTTIPTTTTE--------------KTTPTT-------T 471
            :|||.:..||...:| .|.|.:.||....:.|.||::              :.||.|       |
Worm   595 IFNPYVGECDYSTNVRDCQGYQPTTTPSYSYPKTTSKPYEQPSTTQGYAPIEYTPVTPGYAPQYT 659

  Fly   472 TTTVATTLGPD--QLCDGQELGASFSYPDDCSKYYLCLGGGQWTLAPCIYGSYFDPSTGQCGPDV 534
            :|...|||.|.  .:|..::.|   :|..||.||.:.....:....||..|.|:.....:|....
Worm   660 STIFTTTLSPKYAAMCAKRDDG---NYGFDCEKYLIKCYNRKTFKFPCPSGLYYSRLQDKCDVKE 721

  Fly   535 APDACKPSQVTTTTTTTTTETTTTERN-TTPKSTATTTERTTTTVAPKTGICGGRNENENIAYPN 598
            ..:.|...:.||..|....:...:.:| ...:||......:.||.:|:......|.||.|  |..
Worm   722 NVEGCPEYKPTTDATPAAEQPVISYQNYGYSQSTTKAYNPSVTTPSPQHAAFCERLENGN--YGL 784

  Fly   599 NCTKYIVCVSPIPIAF-FCPDGTFFSSKLEKCIDDWDE--SDCEGDQSTTTLEPGYTRPPPEPTM 660
            :|..|.:..:...... .||.|.|:|....:|  |:.|  .||...:.|.:..|...:|
Worm   785 DCEDYYISCNNFETTINRCPAGLFYSKLNNRC--DYKEHVEDCPEYKPTPSTTPAAEQP------ 841

  Fly   661 CTNSSRDTFPYPDNCQWFIRCVDDYIYMMDVCNCGEYYDPITEKCGADVPSDACRWDYTSTTSTT 725
             ..:...|:.||:                                          .||   ||||
Worm   842 -GTTKYTTYNYPN------------------------------------------IDY---TSTT 860

  Fly   726 SEPTTTTAVTRPPPQKGPCDDVEDGALVAYPNDCSKYIQCDRPIAVAFECEKGDEFSVELGKCV- 789
            ..|..||    |..:...|....|| :.|.|.....|:||.:..::...|..|..::.:.|.|.
Worm   861 PGPVDTT----PLAKAFSCSGRPDG-IYALPYCSQDYVQCMQGRSLISSCAPGLFYNEKNGMCAY 920

  Fly   790 DASLANCSITTTAKPSESTTTPRDGEGSTTPSEPSTGSSTESSTESTTEPSTESTTESTTESTTE 854
            ..::..|.|               |:||
Worm   921 KHTVDTCKI---------------GKGS------------------------------------- 933

  Fly   855 STTESSTGQSTETTESSTVLSTDTSESPSTISTPPSSTTMEPGTTNPEASTTEKPADGICEGKTD 919
                                  |..:|                              ..|.||:|
Worm   934 ----------------------DIIDS------------------------------NACFGKSD 946

  Fly   920 DSLVPYPRNCSK-YIKCQYPIPVGYDCPDGLEFSPTELTCMDP-ELAGCSTKLTTPGLTTLSTEA 982
            ..   |...||. |..|.........||:.|:||.....|:.| :...||.
Worm   947 GY---YSAGCSSYYFSCIDEQIRKMSCPNSLKFSKESEKCVFPIDAKECSI-------------- 994

  Fly   983 SSTPVTTVSTTPEATTTEMST------------TPKTTTTESTTISTTTTDSTTPQTTTTESTTS 1035
                .||:..||.|..::..|            :|.....::....:.|..:.......|::...
Worm   995 ----ATTLDRTPPAVPSDFCTIRSNGLHHLKMCSPHYIVCDNGRAFSGTCIAPLVYNGDTQTCNY 1055

  Fly  1036 KTTTTE--STIISTTPTTTEPTTPKTT-TTESTTIPTTTTESTTATTTPQTTTTESTTISTTPKT 1097
            |:|..:  :..|   |...|.|:..|| ||:....|..||  |.|...||||||..........|
Worm  1056 KSTNKDCGNDYI---PPVAEVTSSYTTYTTKRFEQPAPTT--TAAPYQPQTTTTGKVLYKAAYTT 1115

  Fly  1098 TTTESTTVSTTPTTTESTTISTTPTTTEPTTVSTTPKTTTTESTTVTTTTESTTTVSTPTTLDPY 1162
            |.|:....:|||:....|          |||.:..|..||||:...||||  |.:...|||...|
Worm  1116 TATQYEEPATTPSRDVET----------PTTTTHKPYETTTEAQDATTTT--TASYVAPTTSSAY 1168

Fly 1163 1162
Worm 1169 1168

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4835	NP_647965.3	CBM_14	51..103	CDD:279884	14/54 (26%)
		CBM_14	185..237	CDD:279884	13/52 (25%)
		CBM_14	273..322	CDD:279884	13/48 (27%)
		CBM_14	393..444	CDD:279884	20/52 (38%)
		CBM_14	485..539	CDD:279884	12/53 (23%)
		CBM_14	585..638	CDD:279884	15/55 (27%)
		CBM_14	661..714	CDD:279884	3/52 (6%)
		CBM_14	744..796	CDD:279884	12/52 (23%)
		CBM_14	914..962	CDD:279884	16/49 (33%)
		CBM_14	1175..1212	CDD:279884
C39D10.7	NP_509334.3	CBM_14	29..79	CDD:279884
		CBM_14	98..148	CDD:279884
		CBM_14	189..242	CDD:279884	15/70 (21%)
		ChtBD2	337..384	CDD:214696	13/52 (25%)
		CBM_14	419..467	CDD:279884	13/47 (28%)
		CBM_14	560..612	CDD:279884	20/53 (38%)
		CBM_14	675..726	CDD:279884	12/53 (23%)
		CBM_14	774..825	CDD:279884	15/54 (28%)
		CBM_14	875..927	CDD:279884	12/52 (23%)
		CBM_14	941..992	CDD:279884	16/53 (30%)
		CBM_14	1010..1062	CDD:279884	6/51 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_29YBV
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D487374at33208
OrthoFinder	1	1.000	-	-		FOG0014392
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820