DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4835 and cbd-1

DIOPT Version :9

Sequence 1:	NP_647965.3	Gene:	CG4835 / 38619	FlyBaseID:	FBgn0035607	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	NP_502145.2	Gene:	cbd-1 / 178061	WormBaseID:	WBGene00010351	Length:	1319	Species:	Caenorhabditis elegans

Alignment Length:	1256	Identity:	245/1256 - (19%)
Similarity:	381/1256 - (30%)	Gaps:	438/1256 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 FGALVPYPDNCSLFLVCDCLYPTVKLCPANLWWDNKTQQCNYPQAVECIYYSIETPEPTDGTTRF 120
            |...:.||.:           |....|||....:.....|:...:: |:....:....:|.:..:
Worm    16 FSNSIQYPHS-----------PAATECPAYFNGNIAGNACSREYSI-CVNGVRQAATCSDDSVFY 68

  Fly   121 TPEPTSSTQKITPEPTEPPSSTAKITTESTTGTSTEITSSTPSSYLPTSSWDPPPAPPGISDDYC 185
            ..|       ..|....|.....:.|.|..|               |.:.:|            |
Worm    69 EDE-------CVPVDESPECRVDENTEEDDT---------------PYAEFD------------C 99

  Fly   186 RNKEDGSVHYYPYDC-QAYINCTYGWPVLNYCIEDKVFNKYLGICDTPDMADCEELPLPTTTTEM 249
            .:|:||   .|...| ..:|:|..|...:..|.:..|||:....|    ...|:|:...|||.
Worm   100 TSKQDG---IYSIGCSNQFISCVAGGAYMAKCPDSLVFNERTQDC----RESCDEVKQDTTTA-- 155

  Fly   250 PPTSTTEEDVVCGPTPEGIEEDYCVPKGNGFYEYP----YNCSG-------------YLACKNGC 297
             |....:.:...|.....|..||.....|   |.|    ::|:|             :.:|.|..
Worm   156 -PQVYEDGEEGYGEASGEIAGDYERQPSN---EQPDSIDFDCNGLEDGNYADGCNDVFYSCSNNM 216

  Fly   298 TDLDYCQPDKLFNNWLHICDTPDSVRCDPLPFPTTPGTTNKPTTPSVTTTPSITTTPSTPTTLPS 362
            ....||.|..:||.....||    .:|          ||:.||| :|:.:.|..|||....:..|
Worm   217 VFQRYCPPGTVFNINQQSCD----FQC----------TTDDPTT-TVSYSTSTITTPQEDDSEYS 266

  Fly   363 DGSTTEIHSSTT----EEIVTTTDGL------PSDVDPNDCKDEKDGTIFAYIGNC-SEYLICKD 416
            ..::.::.|:||    :.|.|||.|.      .:...|..|   ::|.:.:: |.| |.:..|::
Worm   267 STTSADVISTTTTPSIDAIETTTTGFDAVTTTTTTQTPFVC---QEGQVNSF-GMCSSRFNRCQN 327

  Fly   417 NQVQMGHCPPNTLFNPDLLVC---------------------DEPDDVVCL-------------- 446
            |.|:...||.||||...|::|                     ..|.|.:..
Worm   328 NSVRSKQCPVNTLFESSLVMCVFDLPQCQPITVPAAPAYNSYGPPSDTIVSPFDENVRLKPKFDR 392

  Fly   447 ------GDRTTTPI--------PTTIP-------------------------------------- 459
                  |..:..|:        |..||
Worm   393 RRKYHHGKPSYGPVNGNSYLENPFFIPRHRGGSHRDHRRYGYGPAIDSPFSTAFRGRAALSDQFK 457

  Fly   460 -------------------------------------TTTTEKTTPTTTTTTVATTLGPDQLCDG 487
                                                 .:..|:..|....:  ...|||.:..||
Worm   458 DYRRARMGKIQGDARKVDGNKRFLIDDEFEGPNAKFVESNIEQVFPKNRHS--KKQLGPHEDPDG 520

  Fly   488 QELGASFSYPD------------------------------------DCSKY------------- 503
            .:...:|...|                                    ||.:|
Worm   521 YDDEKTFDAKDLFGATRRKRSAYYGTEQSVYGQQSAQISARQAQVNKDCQQYTTPTFLTFGDCFD 585

  Fly   504 --YLCLGGGQWTLAPCIYGSYFDPSTGQC---------------GPDVAPDACKPSQVTTTTTTT 551
              ..|.|.|...:|.|..|..||.:...|               |...:.|...||:.......|
Worm   586 QFIFCSGNGINRMAACPIGETFDKTLRSCSETCGVSTTIVAVTIGTQTSDDLSAPSEYIENDGVT 650

  Fly   552 TTETTTTERNTT--PKSTATTTERTTTTVAPKTGIC--GGR-NENENIAYPNNCT-KYIVCVSPI 610
            |..|...:.:||  |.|..:.|.:.::...|.|...  |.| :.:.:..:...|: |||.|.:..
Worm   651 TQSTWNDQPSTTQAPNSYESYTTQYSSNDVPSTSAAPIGDRCSLDASGLFSLGCSQKYIQCSNGA 715

  Fly   611 PIAFFCPDGTFFSSKLEKCIDDWDESDCEGDQSTTTLEPGYTRPPPE--------PTMCTNSSRD 667
            .|...|.:..:|:...::|....:..:| |.|.:|: .|..|.|..:        |:....|:..
Worm   716 AIVRRCGESLYFNEATQECTYRDEVPEC-GSQGSTS-SPVITTPGQDQSSNYYGIPSDDVPSTTQ 778

  Fly   668 TFPYPDNC-------------QWFIRCVDDYIYMMDVCNCGEYYDPITEKC----------GADV 709
            | |..|.|             |.:|:|.|....:.: |....|:|..::.|          .|||
Worm   779 T-PVGDRCAYVASGLFDLGCSQKYIQCSDSAASVRE-CEGSLYFDERSQSCRFRDEVFKCQTADV 841

  Fly   710 PSDAC--RWDYTSTTSTTSEPTTTT----------AVTRPPPQKGPCDDVEDGALVAYPNDCSKY 762
            .|.:.  ..|:|:|.::.||...||          :||..|..  .|..:.||   .:...||.:
Worm   842 SSSSTVPYLDFTTTPASPSEDEPTTYEPSVAPYIPSVTVNPVD--TCTSLSDG---THGTGCSSF 901

  Fly   763 IQCDRPIAVAFECEKGDEFS---VELGKCVDASLANC--------------SITTTA-------- 802
            .         |.|..|...|   .:||:..|.|:..|              .:||.|
Worm   902 Y---------FVCSHGRLISSGNCQLGEGYDPSVQGCRTFSEIPARACDEQEVTTDAGLVQLMPY 957

  Fly   803 KPSE--------STTTPRDGEGSTTPSEPSTGSSTESSTES--TTEPSTESTTESTTESTTESTT 857
            |..|        :||...||...|.    .|||:..|:|:|  .|.|..:.||.:.:....::.:
Worm   958 KTLEEVLTTTEAATTVANDGPTDTY----ITGSTKYSTTDSGEYTIPYGDETTSTRSYDRADNDS 1018

  Fly   858 ESSTGQSTETTESSTVLS--------------TDTS------------ESPSTISTPPSSTTMEP 896
            |.......|..:..||.|              ||..            :|.|....|......|.
Worm  1019 EDEEEDDVEHDQKCTVGSRTPVGFCVRTYLECTDAGNVEKLCRIGKLFDSHSNRCVPRIGCGKEA 1083

  Fly   897 --GTTNPEASTTEKPA-----DGICEGKTDDSLVPYPRNCSKYIKCQYPIPVGYDCPDGLEFSPT 954
              .......:||..||     :|.|.....:::.......|||::|.|.......|.:...||..
Worm  1084 IRDAIKDMIATTPAPAQPKQFEGRCAHVDGEAVFSIGVCSSKYLRCSYGASKLQQCSEDRVFSND 1148

  Fly   955 ELTCMDPELAGCSTKLTTPGL 975
            :|.|:..|.....|....|.:
Worm  1149 KLECIVRESVSACTVPKNPSI 1169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4835	NP_647965.3	CBM_14	51..103	CDD:279884	8/46 (17%)
		CBM_14	185..237	CDD:279884	14/52 (27%)
		CBM_14	273..322	CDD:279884	14/65 (22%)
		CBM_14	393..444	CDD:279884	18/72 (25%)
		CBM_14	485..539	CDD:279884	18/119 (15%)
		CBM_14	585..638	CDD:279884	11/56 (20%)
		CBM_14	661..714	CDD:279884	17/75 (23%)
		CBM_14	744..796	CDD:279884	13/54 (24%)
		CBM_14	914..962	CDD:279884	11/47 (23%)
		CBM_14	1175..1212	CDD:279884
cbd-1	NP_502145.2	ChtBD2	97..141	CDD:214696	14/58 (24%)
		ChtBD2	191..237	CDD:214696	11/49 (22%)
		CBM_14	692..743	CDD:307643	9/50 (18%)
		CBM_14	785..836	CDD:307643	9/51 (18%)
		CBM_14	1108..1161	CDD:307643	12/52 (23%)
		CBM_14	1182..1235	CDD:307643
		CBM_14	1251..1296	CDD:307643
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D487374at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920