DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir64a and GLR3.6

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001326369.1	Gene:	GLR3.6 / 824311	AraportID:	AT3G51480	Length:	903	Species:	Arabidopsis thaliana

Alignment Length:	799	Identity:	137/799 - (17%)
Similarity:	240/799 - (30%)	Gaps:	311/799 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 SEWLEGVLRMEALRQIAVVDLACGAVSRR-----------FLEL--------ASAKMLYSEKFHW 185
            :.||..::..::...:..::...|.::.|           |::.        .|...||:....|
plant   254 TNWLSTIIDTDSPLPLDTINNIQGVITLRLHTPNSIMKQNFVQRWHNLTHVGLSTYALYAYDTVW 318

  Fly   186 LL---IEDFAWHGRTQTAEGSGKRDDGEMEEEEPPGQQIQATDDEDLPSIESFLGGMNLYMNT-- 245
            ||   |:||...|             |.:...:.|              |.|.|||.||:::.
plant   319 LLAQAIDDFFKKG-------------GNVSFSKNP--------------IISELGGGNLHLDALK 356

  Fly   246 ----------------ELTLAKRMSEAAHYTL----FDVWNP-GLNYGGHVNLTEIGSFTPTEGI 289
                            .:.|..||...:...|    |||.|. |..|      |.||
plant   357 VFDGGKIFLESILQVDRIGLTGRMKFTSDRNLVNPAFDVLNVIGTGY------TTIG-------- 407

  Fly   290 QLHTWFRTTSTVRRRMDMQHARVRCMVV--VTNKNMTGTLMYYLTHTMSGH-------------- 338
               .||            .|:.:..|..  :.|.:.:|..::.:  ...||
plant   408 ---YWF------------NHSGLSVMPADEMENTSFSGQKLHSV--VWPGHSIKIPRGWVFSNNG 455

  Fly   339 ----IDTMNRFNFNLLMAVR----------DMFNWTF------VLSRTTSWGYVKNGRFDGMIGA 383
                |...||:.|..:::|:          |:|....      |.....::|   ||..:.....
plant   456 RHLRIGVPNRYRFEEVVSVKSNGMITGFCVDVFIAAINLLPYAVPFELVAFG---NGHDNPSNSE 517

  Fly   384 LIRNET----DIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVWI 444
            |:|..|    |.|...|....||.|..|.. :.:......:....|......:.||:|||..:|:
plant   518 LVRLITTGVYDAGVGDITIITERTKMADFT-QPYVESGLVVVAPVRKLGSSAMAFLRPFTPQMWL 581

  Fly   445 LIVGCGVLTVFILWFLTTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSV 509
            :.....::...::|.|                             :.:..::...|.|     ..
plant   582 IAAASFLIVGAVIWCL-----------------------------EHKHNDEFRGPPR-----RQ 612

  Fly   510 VVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFFVGII 574
            |::                    |.|                           |..|.|||
plant   613 VIT--------------------TFW---------------------------FSFSTLFF---- 626

  Fly   575 CQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLMEK-PKTIKTLSDLVHSSLKVGME 638
               ....:|:...||.::|..|.....|...|:||:...|.:.: ...||.:..|..:...:|..
plant   627 ---SHRETTTSNLGRIVLIIWLFVVLIINSSYTASLTSILTVHQLSSPIKGIETLQTNHDPIGYP 688

  Fly   639 DILYNRDYFLHTKDPVSMELYAKKITSVPTTKENEADE---DEPVDPNPVSTDPAKSYRDIVHSH 700
            ...:.|||.:|     .:.::..::  ||.....|.|:   |.|......:....::|.::..|:
plant   689 QGSFVRDYLIH-----ELNIHVSRL--VPLRSPEEYDKALRDGPGKGGVAAVVDERAYIELFLSN 746

  Fly   701 --ETGAHAKDNAASNWLDPETGLLRHLGFAFHVDVAAAYKIIAETFSEQDICDLTEVSMFPPQKT 763
              |.|...::...:.|           ||||
plant   747 RCEFGIVGQEFTKNGW-----------GFAF---------------------------------- 766

  Fly   764 VSIMQKNSPMRKVISYGLRRVTETGILTYHFNVWHSRKPPCVKKIETSDLHVDMDTVSS------ 822
                .:|||:...:|..:.:::|.|.:....:.|..|| .|  .::.:::.||...:.|
plant   767 ----PRNSPLAVDVSAAILQLSENGDMQRIRDKWLLRK-AC--SLQGAEIEVDRLELKSFWGLFV 824

  Fly   823 ----ALLILLFSYAITLMI 837
                |.::.|..|.: |||
plant   825 VCGVACVLALAVYTV-LMI 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	26/133 (20%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	52/280 (19%)
GLR3.6	NP_001326369.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000