DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir64a and GLR1.4

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_187408.2	Gene:	GLR1.4 / 819940	AraportID:	AT3G07520	Length:	861	Species:	Arabidopsis thaliana

Alignment Length:	969	Identity:	156/969 - (16%)
Similarity:	282/969 - (29%)	Gaps:	407/969 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ELLELELDYGLAEPQRTSLLQSSLILQFSQDYKHIPRITYFTCQKPHLQTPNQIPNA-------A 77
            :||:.|....|...|  |||::..:.:..:..| :|.|:.|       |.|:.:..|       |
plant   104 DLLQTEQVEALVGGQ--SLLEAKNLAELGEKTK-VPVISSF-------QVPSSLSLAKYNYFIQA 158

  Fly    78 EHRDAFAAKNFQLIKSLYESELFVRIVLLDVLAQSPTSGRPN-RPGNGPTGGFSQTPSQAQ---- 137
            .|..:..||....:.|.::....|      ::.:.....|.: :|   ..|.|.|.....:
plant   159 THDTSSEAKGIAALFSNFDWRTAV------LIYEDDDDWRESIQP---LVGHFQQNAIHIEYKAE 214

  Fly   138 ----SNSEWLEGVLRMEALR-------QIAVVDLACGAVSRRFLELASAKMLYSEKFHWLLIEDF 191
                ||.|.:     |:.||       :|.|..:: ..::.|....|....:..|.:.|:|
plant   215 FSVSSNEECI-----MKQLRKFKASGIRIFVAHIS-ERIANRLFPCARRLGMMEEGYAWIL---- 269

  Fly   192 AWHGRTQTAEGSGK-RDDGEMEEEEPPG-----QQIQATDDEDLPSIESFLGGMNLYMNTELTLA 250
                   ||..... :|...:.:||..|     ..|..|::         |....|.....|.|.
plant   270 -------TARSMNNFQDTNYLAKEEMEGVIGFKSYIPLTEE---------LHNFTLRWKRSLRLE 318

  Fly   251 K---RMSEAAHYTLFDVWN----------PGL--------------------------------- 269
            :   |||..:.:.....|:          |||
plant   319 EVVTRMSVCSIWAHDIAWSLARAAEVAKLPGLSVYDLLEAIPESAKHKGLSGDIKFIDKKFISDK 383

  Fly   270 ----NYGGH----VNLTEIGSF--------TPTEGIQLHTW---FRTTSTVRRRMDMQHARVRCM 315
                |..|.    |.|...|||        :.|:.::...|   ......:|...:.:|.:.:.:
plant   384 FEIVNMIGRGERSVGLWNSGSFISNRRRRLSSTKALETIIWPGGSTRIPKIRSLKEKRHGKKKKL 448

  Fly   316 -VVVTNKNMTGTLMYYLTHTMSG-------HIDTMNR----FNFNLLMAVRDMFNW--------- 359
             |:|...|:|..::...|...:|       .||....    ||:.:     :...|
plant   449 RVLVPAGNITPQILEVKTDFKTGVTAATGYCIDVFETSILPFNYEV-----EYIPWPGAINYKNY 508

  Fly   360 ---TFVLSRTTSWGYVKNGRFDGMIGALIRNE------------TDIGGAPIFYWLERHKWIDVA 409
               .:.|       |.:..::|..:|.:...:            ||:|.|.:
plant   509 NDLVYTL-------YSQKDKYDAAVGDITITDNRSLYVDFTLPFTDMGLAVV------------- 553

  Fly   410 GRSWSSRPCFIFRHPRSTQKDR---IVFLQPFTNDVWILIVGCGVLTVFILWFLTTIEWKLVPHD 471
                             |.||:   |:| :|.|..:|:.|....:||..|:|.:..       ||
plant   554 -----------------TAKDKSMWIIF-KPLTLSLWLTIASFFILTGAIVWLIER-------HD 593

  Fly   472 GSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQ 536
            .:                                                :::.|
plant   594 NA------------------------------------------------DFQGS---------- 600

  Fly   537 RCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVS---------GRCIV 592
             |:|::..                            ::|   .||||...:         .|.:|
plant   601 -CFQQIGT----------------------------LLC---FGFSTLVFAHRERLQHNMSRFVV 633

  Fly   593 ITSLLFSFCIYQFYSASIVGTLLMEKPKTIKTLSDLVHSSLKVGMEDILYNRDYFLHTKDPVSME 657
            |..:.....:...|:|::...:.:::.:.:|       |:..:|
plant   634 IVWIFAVLILTSNYTATLTSVMTVQQIRGLK-------SNENIG--------------------- 670

  Fly   658 LYAKKITSVPTTKENEADEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLL 722
            .::..|.:            ..|:.||....|  .|:.:                ...|..|..|
plant   671 FFSASIAA------------NVVNDNPTFQGP--RYKGL----------------KTADDFTNAL 705

  Fly   723 RHLGFAFHVDVAAAYKI-IAETFSEQDICDLTEVSMFPPQKTVSI-------MQKNSPMRKVISY 779
            |:...:|.||.....|: :|:..||           |...:|.|:       .||.||:.:.:|.
plant   706 RNGTISFIVDEVPYVKLFVAKHPSE-----------FVIVETESVTNGFGFAFQKGSPLVQKVSR 759

  Fly   780 GLRRVTETGILTYHFNVWHSRKPPCVKKIETSDLH-VDMDTVSSALLILLFSYAITLMI 837
            .:.::..|..|....|.|..|:.......:|  .| :.:.|.....:|...|:|..|::
plant   760 EIEKLRRTEKLKAIENWWFQRQTTSATSEDT--FHPLTVYTFRGLFMITGVSFAFALIV 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	22/140 (16%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	47/282 (17%)
GLR1.4	NP_187408.2	PBP1_GABAb_receptor	47..410	CDD:107361	65/350 (19%)
		ANF_receptor	64..390	CDD:279440	59/330 (18%)
		GluR_Plant	448..778	CDD:270404	78/538 (14%)
		Periplasmic_Binding_Protein_Type_2	476..>657	CDD:304360	41/320 (13%)
		Lig_chan	570..810	CDD:278489	58/407 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000