Protein Alignment Ir64a and grin2bb

DIOPT Version :10

• Sequence 1: NP_647962.1
• Gene: Ir64a / 38616
• FlyBaseID: FBgn0035604
• Length: 859
• Species: Drosophila melanogaster
• Sequence 2: NP_001121809.1
• Gene: grin2bb / 559976
• ZFINID: ZDB-GENE-061207-27
• Length: 1770
• Species: Danio rerio
• Alignment Length: 892
• Identity: 154/892 - (17%)
• Similarity: 289/892 - (32%)
• Gaps: 295/892 - (33%)

  Fly    16 LPEHELLELELDYGLAEPQ-RTSLLQSSLILQFSQDYKHIPRITYFTCQKPHLQTPNQIPNAAEH 79
            |.|..||::.:|.|.::.| :...|||.:||.:              |.|....|..::    .|
Zfish   273 LEEVLLLDMSVDDGDSKIQNQMKKLQSPVILLY--------------CTKEEATTIFEV----AH 319

  Fly    80 RDAFAAKNFQ-LIKSLYESELFVRIVLLDVLAQSPTSGRPNRPGNGPTGGFSQTPSQAQSNSEWL 143
            ........:. ::.||...:                  ..|.|...|||..|      .|..||.
Zfish   320 SVGLTGYGYTWIVPSLVAGD------------------TDNVPNVFPTGLIS------VSYDEWD 360

  Fly   144 EGVLRMEALRQIAVVDLACGAVSRRFLELASAKMLYSEKFHWLLIEDFAWHGRTQTAEGSGKRDD 208
            .|   :||..:.||..:|          :|::.|:.....|.||  ....|| ....:||...:.
Zfish   361 YG---LEARVRDAVAIIA----------MATSTMMLDRGPHTLL--KSGCHG-APDKKGSKSGNP 409

  Fly   209 GE----MEEEEPPGQQIQATDDEDLPSIESFLGGMNLYMNTELTLAKRMSEAAHYTLFDVWNPG- 268
            .|    :......|:.:..::|           |..::....:.|   :::...|.....|..|
Zfish   410 NEVLRYLMNVTFEGRNLSFSED-----------GFQMHPKLVIIL---LNKERQYERVGKWENGS 460

  Fly   269 --LNY----------------GGHVNLT--EIGSFTPTEGIQ--LHTWFRTTSTVRRRMDMQHAR 311
              :.|                ..|:::.  |...|...|.:.  ..|..|.|...|:::.:|
Zfish   461 LAMKYHVWPRFELYSDAEEREDDHLSIVTLEEAPFVIVEDVDPLSGTCMRNTVPCRKQLKLQ--- 522

  Fly   312 VRCMVVVTNKNMTGTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWGYVK--N 374
                      |:||....|:.....|       |..::|..:.....:|:.|...|:..:.|  |
Zfish   523 ----------NLTGDSGIYIKRCCKG-------FCIDILKKIAKSVKFTYDLYLVTNGKHGKKIN 570

  Fly   375 GRFDGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVFLQPFT 439
            |.::||:|.::.....:....:....||.:.||.:.....:....:......|.... .||:||:
Zfish   571 GTWNGMVGEVVLKNAHMAVGSLTINEERSEVIDFSVPFIETGISVMVSRSNGTVSPS-AFLEPFS 634

  Fly   440 NDVWILIVGCGVLTVFILWFLTTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPI 504
            .|||::        :|::..:                                           :
Zfish   635 ADVWVM--------MFVMLLI-------------------------------------------V 648

  Fly   505 TAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVGLFLESVLF 569
            :||:|.|           :|..:|:.    :.||       :.|  .::...|.          |
Zfish   649 SAVAVFV-----------FEYFSPVG----YNRC-------LAD--GREPGGPS----------F 679

  Fly   570 FVG--IICQQGLGFSTSF-------VSGRCIVITSLLFSFCIYQFYSASIVGTLLMEKPKTIKTL 625
            .:|  |....||.|:.|.       .:.:.:|.....|:......|:|::...::.|:
Zfish   680 TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEE------- 737

  Fly   626 SDLVHSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKITSVPTTKENEADEDEPVDPNPVSTDP- 689
                                             |..::|.:...|....::..|  |....|.|
Zfish   738 ---------------------------------YVDQVTGLSDKKFQHPNDFSP--PFRFGTVPN 767

  Fly   690 -------AKSYRDIVHSHETGAHAKD-NAASNWLDPETGLLRHLGFAFHVDVAAAYKIIAETFSE 746
                   ..:|:: :||:.|..|.|: |.|.:.|  ::|.|.    ||..|.|    ::......
Zfish   768 GSTERNIRNNYKE-MHSYMTSFHQKNVNEALHSL--KSGKLD----AFIYDAA----VLNYMAGR 821

  Fly   747 QDICDLTEVS---MFPPQKTVSIMQKNSPMRKVISYGLRRVTETGILTYHFNVW-----HSRKPP 803
            .:.|.|..:.   :|........:||:|..::.:...:.::...|.:.....:|     |:.|
Zfish   822 DEGCKLVTIGSGYIFATTGYGIAIQKDSGWKRAVDLAILQLFGDGEMEELEALWLTGICHNEK-- 884

  Fly   804 CVKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILYSKWHNR 850
              .::.:|.|  |:|.::....:|..:.|::|:....|.|: .|..|
Zfish   885 --NEVMSSQL--DVDNMAGVFYMLGAAMALSLITFIAEHLF-YWQLR 926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:473866	22/115 (19%)
		Lig_chan	563..828	CDD:459656	48/290 (17%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..465	CDD:380601	50/263 (19%)
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	90/558 (16%)
		NMDAR2_C	919..1770	CDD:463148	3/9 (33%)