DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir64a and grid1b

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	XP_009304811.1	Gene:	grid1b / 557511	ZFINID:	ZDB-GENE-121214-84	Length:	1048	Species:	Danio rerio

Alignment Length:	943	Identity:	175/943 - (18%)
Similarity:	291/943 - (30%)	Gaps:	310/943 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SSLILQFSQDYKHIPRITYFTCQKPHLQTPNQI-PNAAEHRDAFAAK----------------NF 88
            |:..||...|..|||.:......:...:|..|: |:....|...||:                .:
Zfish    98 SASALQSLTDAMHIPHLYVQRNAEGSPRTACQLNPSPDGERYTLAARPPVRLGDVMLTLVGELRW 162

  Fly    89 QLIKSLYESELFVR--IVLLDVLAQSPTSGRPNRPGNGPTGGFSQ--TPSQAQSNSEWLEGVLRM 149
            |.....|:|:..:|  .|.||..::........|.....:|.||.  |..:.:..:.:      .
Zfish   163 QKFIVFYDSDYDIRGLQVFLDQTSRQGLDVSLQRVDRNISGVFSSLFTSMRTEELNRY------R 221

  Fly   150 EALRQIAVVDLACGAVSRRFLELASAKMLYSEKFHWLLIEDFAWHGRTQTAEGSGKRDDGEMEEE 214
            :.||:..::....||  :.|:..|....|.|:..||:.:.:
Zfish   222 DTLRRAILLLSPRGA--QVFIHQAVETNLASKDSHWVFVNE------------------------ 260

  Fly   215 EPPGQQIQATDDEDLPSIESFLGGM---------------------------------------- 239
                   :.:|.|.|....|.||.|
Zfish   261 -------EISDTEILELAHSSLGRMTVVRQIFPLWRDSSVSCMRNSHRISSLLCDPQEGYLQSLE 318

  Fly   240 --NLYM-NTELTLA----KRMSEAAHYTLFDV---------WNPGLNY----------------- 271
              |||: ::.|.||    :::.:...:::..:         ||.|.:.
Zfish   319 VSNLYLYDSVLMLANAFYRKLEDRKWHSMASLNCIRKSTKPWNGGWSMLETIQKGRITGLTGIMD 383

  Fly   272 ------GGHVNLTEIG-SFTPTEG---IQLHTWFR----TTSTVRRRMD--MQHARVRCMV---- 316
                  ..||....:| ||:.|.|   .:|.||..    ..|....|::  ||...|:.:.
Zfish   384 FMENGSNSHVQFEILGTSFSETFGKDIKRLATWDSVHGLNGSLKESRIENGMQGVTVKVVTLLED 448

  Fly   317 --VVTNKNMTGTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWGY---VKNGR 376
              |:..:|:.|....|            ..|:.::|.|:..:..:.:.:.:.....|   :.||.
Zfish   449 PFVMVAENILGQPKRY------------KGFSIDVLEALAKILGFKYDIYQVADSKYGSQLSNGS 501

  Fly   377 FDGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVFL-QPFTN 440
            ::||||.||....|:..:.|....||...:|.:.|........:.|.|.  :|..|..| .||..
Zfish   502 WNGMIGELINKRADLAVSAITITPERENVVDFSKRYMDYSVGILHRKPE--EKINIFSLFAPFDL 564

  Fly   441 DVWILIVGCGVLTVFILWFLTTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPIT 505
            .||..| ...:..|.:|.||.|....|           :...||..|:.......
Zfish   565 AVWACI-AAAIPVVGVLIFLLTRMQML-----------RSQNPPGAHHASSMSNS---------- 607

  Fly   506 AVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFF 570
                                                                      |.|.::.
Zfish   608 ----------------------------------------------------------LHSAIWI 614

  Fly   571 V-GIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLMEK-PKTIKTLSDLVHSSL 633
            | |...|||.......|:.|.::.:..||:..:...|:|::...|.:.: ..||:|..||....
Zfish   615 VYGAFVQQGGDSVVGSVALRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNTIRTFQDLARQM- 678

  Fly   634 KVGMEDILYNRDYFLHTKDPVSMELYAKKITSVPTTKENEADEDEPVDPNPVSTDP--AKSYRDI 696
                 |..|..     .:|....:.:..|.|                  ||:..|.  |:.:|.|
Zfish   679 -----DFAYGT-----VRDSAVYDYFKAKGT------------------NPLEQDSTYAELWRTI 715

  Fly   697 VHSHETGAHAKDNAASNWLDPETGL--LRHLGFAFHVDVAAA-YKIIAETFSEQDICDLTEVSMF 758
              |...|   :|.:.|:   |..|:  .:...:||..|:|.. |..:.:     |.|.:|.....
Zfish   716 --SKNNG---QDFSVSS---PSEGIRKAKKGPYAFLWDMAVVEYAALTD-----DDCTITVSGNS 767

  Fly   759 PPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHFNVWHSRKPPCVKKIETSDLHVDMDTVSS 822
            ...|...| ||..||.|.:||..:..:.|.|.|......|..|...|       ||:...:....
Zfish   768 MSSKGYGIAMQHGSPYRDLISQKILELQEKGDLDVLKQKWWPRTGRC-------DLNSHSNAQPD 825

  Fly   823 ALLILLFSYAITLMILGTEILYSKWHNRIQLKW 855
            ...:.|.|:|....||...:|.:.....:::.|
Zfish   826 GRSLKLHSFAGVFCILAAGLLLACLVAALEMWW 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	31/117 (26%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	61/272 (22%)
grid1b	XP_009304811.1	PBP1_iGluR_delta_1	25..424	CDD:107387	61/364 (17%)
		ANF_receptor	36..400	CDD:279440	53/340 (16%)
		Periplasmic_Binding_Protein_Type_2	437..809	CDD:304360	99/507 (20%)
		Lig_chan	565..840	CDD:278489	76/403 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591120
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740