DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir64a and grik2

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	XP_021322472.1	Gene:	grik2 / 556013	ZFINID:	ZDB-GENE-080414-1	Length:	908	Species:	Danio rerio

Alignment Length:	892	Identity:	158/892 - (17%)
Similarity:	286/892 - (32%)	Gaps:	277/892 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PHLQT--PNQIPNAAEHRDAFAAKNFQLIKSLYESEL----FVR-------------IVLLDVLA 110
            ||:||  .:|:   :::||:|....:....||..:.|    |.:             ::.|..|.
Zfish   128 PHIQTKWKHQV---SDNRDSFYVNLYPDFSSLSRAILDLVHFFKWKTVTVVYDDSTGLIRLQELI 189

  Fly   111 QSPTSGRPNRPGNGPTGGFSQTPSQAQSNSEWLEGVLRMEALRQIAVVDLACG-AVSRRFLELAS 174
            ::|:.......       ..|.|:..:.....|:.:.|.:....|    ..|| .::...|:.|.
Zfish   190 KAPSRYNIRLK-------IRQLPADTKDAKPLLKEMKRGKEFHVI----FDCGHEMAAGILKQAL 243

  Fly   175 AKMLYSEKFHWLL---------IEDFAWHG---------RTQTAEGSGKRDDGEMEEEEPPGQQI 221
            |..:.:|.:|::.         :|.:.:.|         .|:.::.|...:...||..:.|
Zfish   244 AMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENSQVSSIIEKWSMERLQAP---- 304

  Fly   222 QATDDEDLPSIESFLGGMNLYMNTELTLAKRMSEAAHYTLFDV------------------WNPG 268
                    |..:|  |.::.:|.|:..|   |.:|.|.....|                  |..|
Zfish   305 --------PKPDS--GLLDGFMTTDAAL---MYDAVHVVAVAVQQSPQITVSSLQCNRHKPWRFG 356

  Fly   269 LNY------------GGHVN----------------------LTEIGSFTPTEGIQLHTWFRTTS 299
            ..:            .|.:|                      |.:||::.|..|:.: |..:...
Zfish   357 NRFMTLIKEAHWDGLTGRINFNRTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNM-TENQKGK 420

  Fly   300 TVRRRMDMQHARVRCMVVVTNKNMTGTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNWTFVLS 364
            |......:.:   |.:||.|.......:.......:.|: |....:..:||..:..:..:.:.|.
Zfish   421 TANVTDSLSN---RSLVVSTILEEPYVMFKKSDKPLYGN-DRFEGYCVDLLRELAAILGFGYELR 481

  Fly   365 RTTSWGY----VKNGRFDGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPR 425
            ......|    ..:|:::||:..|:.::.|:..||:.....|.|.||.:....:.....::|.|.
Zfish   482 LVEDGRYGAQDESSGQWNGMVRELMDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPN 546

  Fly   426 STQKDRIVFLQPFTNDVW--ILIVGCGVLTV-FILWFLTTIEWKLVPHDGSALIKPKGGAPPRHH 487
            .|......||.|.:.|:|  ||:...||..| |::...:..|| ..||
Zfish   547 GTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEW-YNPH----------------- 593

  Fly   488 YQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAK 552
                        |..|                     ||..::            |.:
Zfish   594 ------------PCNP---------------------DSDVVE------------NNF------- 606

  Fly   553 QKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLME 617
                     ..|.|..|.||.:.|||.......:|.|.:......|:..|...|:|::...|.:|
Zfish   607 ---------TLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVE 662

  Fly   618 KPKT-IKTLSDLV-HSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKITSVPTTKENEADEDEPV 680
            :.:: |.:..||. .:.::.|:            .:|..:|..:.|       ||.:..|:
Zfish   663 RMESPIDSADDLAKQTKIEYGV------------VEDGSTMTFFKK-------TKISTYDK---- 704

  Fly   681 DPNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHLGFAFHVDVAAAYKIIAET-- 743
                        ..:.:.|.......|        ..|.|:.|.|        .:.|..:.|:
Zfish   705 ------------MWEFMSSRRHSVMVK--------SIEEGIERVL--------TSDYAFLMESTT 741

  Fly   744 --FSEQDICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHF---NVWHSRKP 802
              |..|..|:||::......|...: ....||.|..|:..:.::.|.|.|  |.   ..|.....
Zfish   742 IEFVTQRNCNLTQIGGLIDSKAYGVGTPMGSPYRDKITIAILQLQEEGKL--HMMKEKWWRGNGC 804

  Fly   803 PCVKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILYSKWHN 849
            |..:..|.|.|.|  ..:....::|.....:::.:...|.||....|
Zfish   805 PEEENKEASALGV--QNIGGIFIVLAAGLVLSVFVAVGEFLYKSKQN 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	27/120 (23%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	54/274 (20%)
grik2	XP_021322472.1	PBP1_iGluR_Kainate	37..414	CDD:380605	53/317 (17%)
grik2	XP_021322472.1	Periplasmic_Binding_Protein_Type_2	430..800	CDD:419667	92/505 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591561
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840