Protein Alignment Ir64a and grik2

DIOPT Version :10

• Sequence 1: NP_647962.1
• Gene: Ir64a / 38616
• FlyBaseID: FBgn0035604
• Length: 859
• Species: Drosophila melanogaster
• Sequence 2: NP_001410875.1
• Gene: grik2 / 556013
• ZFINID: ZDB-GENE-080414-1
• Length: 908
• Species: Danio rerio
• Alignment Length: 892
• Identity: 158/892 - (17%)
• Similarity: 286/892 - (32%)
• Gaps: 277/892 - (31%)

  Fly    65 PHLQT--PNQIPNAAEHRDAFAAKNFQLIKSLYESEL----FVR-------------IVLLDVLA 110
            ||:||  .:|:   :::||:|....:....||..:.|    |.:             ::.|..|.
Zfish   128 PHIQTKWKHQV---SDNRDSFYVNLYPDFSSLSRAILDLVHFFKWKTVTVVYDDSTGLIRLQELI 189

  Fly   111 QSPTSGRPNRPGNGPTGGFSQTPSQAQSNSEWLEGVLRMEALRQIAVVDLACG-AVSRRFLELAS 174
            ::|:.......       ..|.|:..:.....|:.:.|.:....|    ..|| .::...|:.|.
Zfish   190 KAPSRYNIRLK-------IRQLPADTKDAKPLLKEMKRGKEFHVI----FDCGHEMAAGILKQAL 243

  Fly   175 AKMLYSEKFHWLL---------IEDFAWHG---------RTQTAEGSGKRDDGEMEEEEPPGQQI 221
            |..:.:|.:|::.         :|.:.:.|         .|:.::.|...:...||..:.|
Zfish   244 AMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENSQVSSIIEKWSMERLQAP---- 304

  Fly   222 QATDDEDLPSIESFLGGMNLYMNTELTLAKRMSEAAHYTLFDV------------------WNPG 268
                    |..:|  |.::.:|.|:..|   |.:|.|.....|                  |..|
Zfish   305 --------PKPDS--GLLDGFMTTDAAL---MYDAVHVVAVAVQQSPQITVSSLQCNRHKPWRFG 356

  Fly   269 LNY------------GGHVN----------------------LTEIGSFTPTEGIQLHTWFRTTS 299
            ..:            .|.:|                      |.:||::.|..|:.: |..:...
Zfish   357 NRFMTLIKEAHWDGLTGRINFNRTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNM-TENQKGK 420

  Fly   300 TVRRRMDMQHARVRCMVVVTNKNMTGTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNWTFVLS 364
            |......:.:   |.:||.|.......:.......:.|: |....:..:||..:..:..:.:.|.
Zfish   421 TANVTDSLSN---RSLVVSTILEEPYVMFKKSDKPLYGN-DRFEGYCVDLLRELAAILGFGYELR 481

  Fly   365 RTTSWGY----VKNGRFDGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPR 425
            ......|    ..:|:::||:..|:.::.|:..||:.....|.|.||.:....:.....::|.|.
Zfish   482 LVEDGRYGAQDESSGQWNGMVRELMDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPN 546

  Fly   426 STQKDRIVFLQPFTNDVW--ILIVGCGVLTV-FILWFLTTIEWKLVPHDGSALIKPKGGAPPRHH 487
            .|......||.|.:.|:|  ||:...||..| |::...:..|| ..||
Zfish   547 GTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEW-YNPH----------------- 593

  Fly   488 YQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAK 552
                        |..|                     ||..::            |.:
Zfish   594 ------------PCNP---------------------DSDVVE------------NNF------- 606

  Fly   553 QKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLME 617
                     ..|.|..|.||.:.|||.......:|.|.:......|:..|...|:|::...|.:|
Zfish   607 ---------TLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVE 662

  Fly   618 KPKT-IKTLSDLV-HSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKITSVPTTKENEADEDEPV 680
            :.:: |.:..||. .:.::.|:            .:|..:|..:.|       ||.:..|:
Zfish   663 RMESPIDSADDLAKQTKIEYGV------------VEDGSTMTFFKK-------TKISTYDK---- 704

  Fly   681 DPNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHLGFAFHVDVAAAYKIIAET-- 743
                        ..:.:.|.......|        ..|.|:.|.|        .:.|..:.|:
Zfish   705 ------------MWEFMSSRRHSVMVK--------SIEEGIERVL--------TSDYAFLMESTT 741

  Fly   744 --FSEQDICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHF---NVWHSRKP 802
              |..|..|:||::......|...: ....||.|..|:..:.::.|.|.|  |.   ..|.....
Zfish   742 IEFVTQRNCNLTQIGGLIDSKAYGVGTPMGSPYRDKITIAILQLQEEGKL--HMMKEKWWRGNGC 804

  Fly   803 PCVKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILYSKWHN 849
            |..:..|.|.|.|  ..:....::|.....:::.:...|.||....|
Zfish   805 PEEENKEASALGV--QNIGGIFIVLAAGLVLSVFVAVGEFLYKSKQN 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:473866	27/120 (23%)
		Lig_chan	563..828	CDD:459656	54/274 (20%)
grik2	NP_001410875.1	PBP1_iGluR_Kainate	37..414	CDD:380605	53/317 (17%)
		Periplasmic_Binding_Protein_Type_2	430..800	CDD:473866	92/505 (18%)