Protein Alignment Ir64a and Grik2

DIOPT Version :10

• Sequence 1: NP_647962.1
• Gene: Ir64a / 38616
• FlyBaseID: FBgn0035604
• Length: 859
• Species: Drosophila melanogaster
• Sequence 2: NP_062182.1
• Gene: Grik2 / 54257
• RGDID: 2733
• Length: 908
• Species: Rattus norvegicus
• Alignment Length: 898
• Identity: 159/898 - (17%)
• Similarity: 291/898 - (32%)
• Gaps: 289/898 - (32%)

  Fly    65 PHLQT--PNQIPNAAEHRDAFAAKNFQLIKSLYESEL----FVR-------------IVLLDVLA 110
            ||:||  .:|:   ::::|:|....:....||..:.|    |.:             ::.|..|.
  Rat   128 PHIQTRWKHQV---SDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELI 189

  Fly   111 QSPTSGRPNRPGNGPTGGFSQTPSQAQSNSEWLEGVLRMEALRQIAVV-----DLACGAVSRRFL 170
            ::|:  |.|....     ..|.|:..:.....|:   .|:..::..|:     ::|.|     .|
  Rat   190 KAPS--RYNLRLK-----IRQLPADTKDAKPLLK---EMKRGKEFHVIFDCSHEMAAG-----IL 239

  Fly   171 ELASAKMLYSEKFHWLL---------IEDFAWHG---------RTQTAEGSGKRDDGEMEEEEPP 217
            :.|.|..:.:|.:|::.         :|.:.:.|         .|:..:.|...:...||..:.|
  Rat   240 KQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAP 304

  Fly   218 GQQIQATDDEDLPSIESFLGGMNLYMNTELTLAKRMSEAAHYTLFDV------------------ 264
                        |..:|  |.::.:|.|:..|   |.:|.|.....|
  Rat   305 ------------PKPDS--GLLDGFMTTDAAL---MYDAVHVVSVAVQQFPQMTVSSLQCNRHKP 352

  Fly   265 WNPGLNY------------GGHV----------------------NLTEIGSFTPTEGIQLHTWF 295
            |..|..:            .|.:                      .|.:||::.|..|:.:
  Rat   353 WRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNM---- 413

  Fly   296 RTTSTVRRRMDMQHA-RVRCMVVVTNKNMTGTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNW 359
             |.|...:..::..: ..|.::|.|.......|.......:.|: |....:..:||..:..:..:
  Rat   414 -TESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGN-DRFEGYCIDLLRELSTILGF 476

  Fly   360 TFVLSRTTSWGYVK----NGRFDGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFI 420
            |:.:.......|..    ||:::||:..||.::.|:..||:.....|.|.||.:....:.....:
  Rat   477 TYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISIL 541

  Fly   421 FRHPRSTQKDRIVFLQPFTNDVW--ILIVGCGVLTV-FILWFLTTIEWKLVPHDGSALIKPKGGA 482
            :|.|..|......||.|.:.|:|  :|:...||..| |::...:..|| ..||
  Rat   542 YRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFSPYEW-YNPH------------ 593

  Fly   483 PPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIK 547
                             |..|                     ||..::            |.:
  Rat   594 -----------------PCNP---------------------DSDVVE------------NNF-- 606

  Fly   548 DRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVG 612
                          ..|.|..|.||.:.:||.......:|.|.:......|:..|...|:|::..
  Rat   607 --------------TLLNSFWFGVGALMRQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAA 657

  Fly   613 TLLMEKPKT-IKTLSDLV-HSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKITSVPTTKENEAD 675
            .|.:|:.:: |.:..||. .:.::.|.            .:|..:|..:.|
  Rat   658 FLTVERMESPIDSADDLAKQTKIEYGA------------VEDGATMTFFKK-------------- 696

  Fly   676 EDEPVDPNPVST-DPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHLGFAFHVDVAAAYKI 739
                   :.:|| |...::   :.|.......|.|        |.|:.|.|        .:.|..
  Rat   697 -------SKISTYDKMWAF---MSSRRQSVLVKSN--------EEGIQRVL--------TSDYAF 735

  Fly   740 IAET----FSEQDICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHF---NV 796
            :.|:    |..|..|:||::......|...: ....||.|..|:..:.::.|.|.|  |.   ..
  Rat   736 LMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKL--HMMKEKW 798

  Fly   797 WHSRKPPCVKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILYSKWHN 849
            |.....|..:..|.|.|.|  ..:....::|.....:::.:...|.||....|
  Rat   799 WRGNGCPEEESKEASALGV--QNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKN 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:473866	28/120 (23%)
		Lig_chan	563..828	CDD:459656	54/275 (20%)
Grik2	NP_062182.1	PBP1_iGluR_Kainate	37..414	CDD:380605	53/325 (16%)
		Periplasmic_Binding_Protein_Type_2	430..800	CDD:473866	93/503 (18%)