DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir64a and grid2

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001004123.1	Gene:	grid2 / 448841	ZFINID:	ZDB-GENE-040913-1	Length:	1009	Species:	Danio rerio

Alignment Length:	714	Identity:	133/714 - (18%)
Similarity:	239/714 - (33%)	Gaps:	225/714 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 MLYSEKFHWLLIEDFAWHGRTQTA---EGSGKRDDGE--MEEEEPPG-----QQIQATDDEDLPS 231
            :|.:..||..| ||..||.....:   :||.....|:  :|..:..|     ..::..|:...|:
Zfish   332 LLLANTFHRKL-EDRKWHSMASLSCIRKGSKPWQGGKSMLETVKKGGVSGLTSLLEFNDNGSNPN 395

  Fly   232 IESFLGGMNLYMNTELTLAKRMSEAAHYTLFDVWNPGLNYG---GHVNLTEIGSFTPTEGIQLHT 293
            |                         |:.:.     |.|||   |. .::.:.::.|..|:
Zfish   396 I-------------------------HFEIL-----GTNYGEDRGR-GVSRLATWDPIHGL---- 425

  Fly   294 WFRTTSTVRRRMDMQHARVRCMVVVTNKNMTGTLMYYLT----------HTMSGHIDTMNRFNFN 348
              ..|.|.|:               ...||.|.::..:|          ..:.|.......|:.:
Zfish   426 --NGTLTDRK---------------LENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSID 473

  Fly   349 LLMAVRDM--FNWTFVLSRTTSWGYVK-NGRFDGMIGALIRNETDIGGAPIFYWLERHKWIDVAG 410
            :|.|:.:.  |.:...::....:|..: :|.::|:||.|:....|:|.:.:....||...:|...
Zfish   474 VLDALANYLGFKYEIYVAPDHKYGSQQADGTWNGLIGELVFKRADVGLSALTITPERESVVDFTT 538

  Fly   411 RSWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVWILIVGCGVLTVFILWFLTTIEWKLVPHDGSAL 475
            |........:.|....| .|....|.||...:|..|.|..:|...:::.|..:.
Zfish   539 RYMDYSVGVLLRKAERT-VDMFACLAPFDLSLWACIAGTVLLVGTLVYLLNWLN----------- 591

  Fly   476 IKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQ 540
                   |||                .|:.:||                 ||     ||:
Zfish   592 -------PPR----------------LPMGSVS-----------------ST-----TLY----- 606

  Fly   541 KLNKYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQF 605
                                    .|:.|..|...|||.....:.::.|.::....||:..:...
Zfish   607 ------------------------NSMWFVYGSFVQQGGEVPYTTLATRMMMGVWWLFALIVISS 647

  Fly   606 YSASIVGTLLMEK-PKTIKTLSDLVHSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKITSVP-- 667
            |:|::...|.:.: ..:|::|.||.                                |.|.:|
Zfish   648 YTANLAAFLTISRIENSIQSLQDLA--------------------------------KQTDLPYG 680

  Fly   668 TTKENEA-DEDEPVDPNPVSTDP--AKSYRDIVHSHETGAHAKDNAASNWLDPETGL--LRHLGF 727
            |..::.. |:......||...||  ::.:|.|   :.||     .|.:|..:.:.|:  :::..|
Zfish   681 TVLDSAVYDQVRSKGMNPFERDPMYSQMWRMI---NRTG-----GAENNVEESKEGIRKVKYGRF 737

  Fly   728 AFHVDVAAAYKIIAETFSEQDICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILT 791
            ||..| ||..:.:|  .:::| |.|..||.....:...: ||..||.|.:.|..:..:.:.|.:.
Zfish   738 AFVWD-AAVLEYVA--INDED-CSLYTVSNNVADRGYGMAMQHGSPYRDIFSQRILELQQNGDMD 798

  Fly   792 YHFNVWHSRKPPCVKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILYSKWHNRIQLKW 855
            .....|..|..||       ||:..:.|..|...:.:.|:|....:|...::.|.....::..|
Zfish   799 ILKLKWWPRDSPC-------DLYSPVGTRKSGSALDIHSFAGVFFVLAAGVVLSCLIATVETWW 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	25/116 (22%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	59/273 (22%)
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..427	CDD:107386	24/132 (18%)
		ANF_receptor	42..404	CDD:279440	18/102 (18%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	92/495 (19%)
		Lig_chan	568..841	CDD:278489	77/408 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591509
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740