DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir64a and CG11155

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster

Alignment Length:	957	Identity:	165/957 - (17%)
Similarity:	302/957 - (31%)	Gaps:	317/957 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QRTSLLQSSLILQFSQDYKHIPRITYFTCQK----------------------PHLQT---PNQI 73
            ::|.|..:.|:    .|.:::||...|...|                      .|:|:   ...|
  Fly    72 EKTLLPNTQLV----YDIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDI 132

  Fly    74 PNAAEHRD-AFAAKNFQLIKSLYESELFVRIVLLDVLA----------QSPTSGRPNRPGNGPTG 127
            |:.....| .:.:|.|.:  :||.|...:.:...|::.          .....|..|..
  Fly   133 PHIEGRIDLEYNSKEFSI--NLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYGLFNLM------ 189

  Fly   128 GFSQTPSQA-----QSNSEWLEGVLRMEALRQ----IAVVDLACGAVSRRFLELASAKMLYSEKF 183
             .|.|.::|     |::.:....|||  |:||    ..:||.....:...|..:...:| ...::
  Fly   190 -HSSTETKAEMYIRQASPDSYRQVLR--AIRQKEIYKIIVDTNPSHIKSFFRSILQLQM-NDHRY 250

  Fly   184 HWLL---------IEDFAWHGRTQTA----EGSGKR---DDGEMEEEEPPG-------QQIQATD 225
            |::.         :|||.::....||    :...||   ...:|::.:..|       ..||...
  Fly   251 HYMFTTFDLETYDLEDFRYNSVNITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYIQTES 315

  Fly   226 DEDLPSIESFLGGM---------NLYMNTELTLAKRMSEAAHYTLFDVWNPGLNYGGHVN----- 276
            .....|:.:|..|:         |.|:       |.:|..:..|    ||.|::....:|
  Fly   316 ALMFDSVYAFANGLHFLNLDNHQNFYI-------KNLSCTSDQT----WNDGISLYNQINAAITD 369

  Fly   277 ---------------------------LTEIGSFTPTEGIQLH--TWF------RTTSTVRRRMD 306
                                       :.::|.:.|.:|:.:.  |.|      ..|..|..|.:
  Fly   370 GLTGTVQFVEGRRNIFKLDILKLKQEKIQKVGYWHPDDGVNISDPTAFYDSNIANITLVVMTREE 434

  Fly   307 MQHARVRCMVVVTNKNMTGTLMY--YLTHTMSGHIDTMNRFNFNLLMAVRDMFNWTFVLSRTTSW 369
            ..:..|:     .:||:||.|.:  :....:.. |.|...|.:.:.:...:|:.  ..:..|.||
  Fly   435 RPYVMVK-----EDKNLTGNLRFEGFCIDLLKA-IATQVGFQYKIELVPDNMYG--VYIPETNSW 491

  Fly   370 GYVKNGRFDGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVF 434
                    :|::..|:....|:..|.:.....|...||......:.....:|:.|.|.......|
  Fly   492 --------NGIVQELMERRADLAVASMTINYARESVIDFTKPFMNLGIGILFKVPTSQPTRLFSF 548

  Fly   435 LQPFTNDVWILIVGCGVLTVFILWFL---TTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQ 496
            :.|...::|:.::...:|..|.|:.:   :..||| .||.
  Fly   549 MNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWK-NPHP------------------------- 587

  Fly   497 VEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVG 561
                                                     ||            |:....|...
  Fly   588 -----------------------------------------CY------------KETDIVENQF 599

  Fly   562 LFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFC--IYQFYSASIVGTLLMEKP-KTIK 623
            ....|..|..|...:||.|.:....|.|  ::....|.||  |...|:|::...|.:|:. ..|:
  Fly   600 SISNSFWFITGTFLRQGSGLNPKATSTR--IVGGCWFFFCLIIISSYTANLAAFLTVERMISPIE 662

  Fly   624 TLSDLVHSSLKVGMEDILY-------NRDYFLHTKDPVSMELYAKKITSVPTTKENEADEDEPVD 681
            :.|||...:      :|.|       ...:|..:|    :.:|.|....:...|
  Fly   663 SASDLAEQT------EISYGTLEGGSTMTFFRDSK----IGIYQKMWRYMENRK----------- 706

  Fly   682 PNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHLGFAFHVDVAAAYKIIAETFSE 746
                :....|:|.|.:.....|::|       :|...|.|                     .::.
  Fly   707 ----TAVFVKTYEDGIKRVMEGSYA-------FLMESTML---------------------DYAV 739

  Fly   747 QDICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHFNVWHSRKPPCV----K 806
            |..|:||::......|...| ..|.||.|..||..:..:.|.||:...::.|........    |
  Fly   740 QRDCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDK 804

  Fly   807 KIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILYSKWHNRIQL 853
            ..|:....:.::.:....::||...|:.:::...|..   |::|..|
  Fly   805 SKESKANALGVENIGGVFVVLLCGLALAVVVAIFEFC---WNSRKNL 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	20/116 (17%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	53/279 (19%)
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	62/364 (17%)
		ANF_receptor	61..393	CDD:279440	59/347 (17%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	92/518 (18%)
		Lig_chan	555..829	CDD:278489	68/407 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462974
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840