DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir64a and Ir75d

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster

Alignment Length:	737	Identity:	157/737 - (21%)
Similarity:	262/737 - (35%)	Gaps:	237/737 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 EHRDAFAAKNFQLIKSLYESELFVRIVLLDVLAQSPTSGRPNRPGNGPTGGFSQTPSQAQSNSEW 142
            ||:||...|:|....|.:....|    ||..|                               .:
  Fly   109 EHKDAPPPKSFHANNSTHWETSF----LLPAL-------------------------------PY 138

  Fly   143 LEGVLRMEALRQIAVVDLACGAVSRRFLELASAKMLYSEKFHWLLIEDFAWHGRTQTAEGSGKRD 207
            ..|:|.:|...:.|:..|...|        ||....::....|||:.:                |
  Fly   139 KMGILLLEFSSECALNLLRWSA--------ASEHNYFTTNRFWLLLTE----------------D 179

  Fly   208 DGE---MEEEE---PPGQQIQATDDEDLPSIESFLGGMNLYMNTELTLAKRMSEAAHYTLFDVWN 266
            .|:   :|:.|   ||..:::....|::.:....|  ::||           ..||       |.
  Fly   180 PGDIDLLEDPEIFIPPDSELRVLHYENVGNFSCSL--IDLY-----------KVAA-------WK 224

  Fly   267 PGLNYGGHVNLTEIGSFTPTEGIQLHTWFRTTSTVRRRMDMQHARVRCMVVVTNKNMTGTLMYYL 331
            |       :..|.:|.........:|......|.:..|.|::.......:|:...:    |...:
  Fly   225 P-------LKRTLVGHNIRNSRHVIHALQHFGSAITYRQDLEGIVFNSAIVIAFPD----LFTNI 278

  Fly   332 THTMSGHIDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWGYVK-NGRFDGMIGALIRNETDIGGAP 395
            ......||||:::.|..|::.:.:..|.::...:|.::|:.: ||.|||::|...|.|.|:....
  Fly   279 EDLSLRHIDTISKVNHRLMLELANRLNMSYNTYQTVNYGWRQPNGSFDGLMGRFQRYELDLAQLA 343

  Fly   396 IFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVWILIVGCGVLTVFILWFL 460
            ||..|:|...:|....::..|...:||.|..:....| |..||.||||:.|:...::|..:|
  Fly   344 IFMRLDRIALVDFVAETYRVRAGIMFRQPPLSAVANI-FAMPFENDVWVSILMLLIITTVVL--- 404

  Fly   461 TTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYED 525
             .:|....||:                                                    .|
  Fly   405 -VLELFFSPHN----------------------------------------------------HD 416

  Fly   526 STPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRC 590
            .:                                   :::::.|..|.:||||........|.|.
  Fly   417 MS-----------------------------------YMDTLNFVWGAMCQQGFYVEVRNRSARI 446

  Fly   591 IVITSLLFSFCIYQFYSASIVGTLLMEKPKTIKTLSDLVHSSLKVGMEDILYNRDYFLHTKDPVS 655
            ||.|:.:.:..::..:||:|| .||......|::||||..|.|::|::|..||:.||..:.|||:
  Fly   447 IVFTTFVAALFLFTSFSANIV-ALLQSPSDAIQSLSDLGQSPLEIGVQDTQYNKIYFTESTDPVT 510

  Fly   656 MELYAKKITSVPTTKENEADEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPE-- 718
            ..||.|||          |.:.|.:...|:                             |..|
  Fly   511 KNLYHKKI----------ASKGENIYMRPL-----------------------------LGMEKM 536

  Fly   719 -TGLLRHLGFAFHVDVAAAYKIIAETFSEQDICDLTEVSMFPPQKTVSIMQKNSPMRKVISYGLR 782
             |||     ||:.|::.|.|:|:::||||.:.|.|.|:..|.........:||.|.:::|...||
  Fly   537 RTGL-----FAYQVELQAGYQIVSDTFSEPEKCGLMELEPFQLPMLAIPTRKNFPYKELIRRQLR 596

  Fly   783 RVTETGILTYHFNVWHSRKPPC 804
            ...|..::......|..:||.|
  Fly   597 WQREVSLVNREERKWIPQKPKC 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	32/114 (28%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	71/245 (29%)
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	56/276 (20%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	81/367 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469556
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840