DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir64a and gria3b

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_938174.1	Gene:	gria3b / 368416	ZFINID:	ZDB-GENE-030616-53	Length:	883	Species:	Danio rerio

Alignment Length:	846	Identity:	154/846 - (18%)
Similarity:	279/846 - (32%)	Gaps:	239/846 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 DAFAAKNFQL----IKSLYESELFVRIV-----------LLD--------VLAQSPTSGRPNRP- 121
            :|..|.|:|:    :.|:.:.:.|.||:           |:|        :|.|..|.|:.:|.
Zfish   169 EAAVANNWQVTARSVGSITDPQEFRRIIEEMDRRQEKRYLIDCEVDRINVILEQVVTLGKNSRGY 233

  Fly   122 -------------------GNGPTGGFSQTPSQAQSNSEWLEGVLRMEALRQIAVVDLACGAVSR 167
                               |.....||.....:.....::|:...|::               .|
Zfish   234 HYIIANLGFTNISLDKVFLGGANISGFQIINPENLVVQQFLQRWDRLD---------------ER 283

  Fly   168 RFLELASAKMLYSEKFHW---LLIEDFAWHGRTQTAEGS--GKRDDGEMEEEEPPGQQIQATDDE 227
            .|.|..:..:.|:....:   |:|.:...:.|.|..:.|  |...|.......|..|.|......
Zfish   284 EFPEAKNTPLKYTSALSYDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERAL 348

  Fly   228 DLPSIESFLGGMNLYMNTELTLAKRMSEAAHYTLFDVWNPGLNYGGHVNLTEIGSFTPTEGIQLH 292
            .:..::...|  |:..::       .....:||: ||:.  :..||...:.....|.....|...
Zfish   349 KMVQVQGMTG--NIQFDS-------FGRRTNYTI-DVYE--MKTGGPRKIGYWNEFERFVNIMDQ 401

  Fly   293 TWFRTTSTVRRRMDMQHARVRCMVVVTNKN---MTGTLMYY-----LTHTMSGHIDTMNRFNFNL 349
            .:...:|:|..|..:....:....|:..||   :.|...|.     |...::.|:..  ::..::
Zfish   402 QFTNDSSSVENRTIVVTTIMEAPYVMYKKNHMHLEGNEKYEGYCVDLASEIAKHVGI--KYRLSI 464

  Fly   350 LM----AVRDMFNWTFVLSRTTSWGYVKNGRFDGMIGALIRNETDIGGAPIFYWLERHKWIDVAG 410
            :|    ..||        ..|.||        :||:|.|:....||..||:...|.|.:.||.:.
Zfish   465 VMDGKYGARD--------PETKSW--------NGMVGELVYGRADIAVAPLTITLVREEVIDFSK 513

  Fly   411 RSWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVWILIV----GCGVLTVFILWFLTTIEWKLVPHD 471
            ...|.....:.:.|:.::.....||.|...::|:.||    |..|: :|::...:..||:|
Zfish   514 PFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVV-LFLVSRFSPYEWQL---- 573

  Fly   472 GSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQ 536
                                                         :|..|..:..||.|
Zfish   574 ---------------------------------------------DETDEVKDPQTPPD------ 587

  Fly   537 RCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFC 601
                               .|...|:| .|:.|.:|...|||...|...:|||.:......|:..
Zfish   588 -------------------PPNDFGIF-NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLI 632

  Fly   602 IYQFYSASIVGTLLMEK-PKTIKTLSDLV-HSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKIT 664
            |...|:|::...|.:|: ...|::..||. .:.:..|..|....:::|..:|..|..::::...:
Zfish   633 IISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKS 697

  Fly   665 SVPTTKENEADEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHLGFAF 729
            :.|:..                   ||:..|.|      |..:.:...              |||
Zfish   698 AEPSVF-------------------AKTTPDGV------ARVRKSKGK--------------FAF 723

  Fly   730 HVDVAAAYKIIAETFSEQDICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYH 793
            .::     ..:.|...::..||..:|......|...: ..|.|.:|..::..:.::.|.|:|...
Zfish   724 LLE-----STMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKL 783

  Fly   794 FNVWHSRKPPC-----VKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILYSKWHNRIQL 853
            .|.|...|..|     ..|.:||.|  .:..|:....||:....:.:|:...|..|.......:|
Zfish   784 KNKWWYDKGECGSGGGDSKDKTSAL--SLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAEAKRL 846

  Fly   854 K 854
            |
Zfish   847 K 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	29/121 (24%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	55/272 (20%)
gria3b	NP_938174.1	Periplasmic_Binding_Protein_Type_1	25..396	CDD:299141	43/253 (17%)
		ANF_receptor	36..379	CDD:279440	40/236 (17%)
		PBP2_iGluR_AMPA	412..794	CDD:270433	95/519 (18%)
		Lig_chan	544..824	CDD:278489	72/401 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591579
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840