Protein Alignment Ir64a and GluRIIA

DIOPT Version :10

• Sequence 1: NP_647962.1
• Gene: Ir64a / 38616
• FlyBaseID: FBgn0035604
• Length: 859
• Species: Drosophila melanogaster
• Sequence 2: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Alignment Length: 893
• Identity: 156/893 - (17%)
• Similarity: 280/893 - (31%)
• Gaps: 330/893 - (36%)

  Fly    11 LSCQGLPEHELLELELDYGLAEPQRTSLL------QSSLILQFSQDYKHIPRITYFTCQKPHLQT 69
            |.|:.....|||::.:|:.|..|.|...|      .|.|...:::|:|  ..||     ...|:.
  Fly   223 LDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFK--ANIT-----SVRLKV 280

  Fly    70 PNQIPNAAEHRDAFAAKNFQLIK--SLYESELFVRIVLLDVLAQSPTSGR-------PNRPGNGP 125
            .:..|        |..|..:|.|  .:..::..:.|::.|.:....:|.|       |..|.|..
  Fly   281 VDANP--------FERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARNVIAAMQPFHPPNRH 337

  Fly   126 TGGFSQTPSQAQSNSEWLEGVLRMEALRQIAVVDLACGAVSRRFLELASAKMLYSEKFHWLLIED 190
            .|          |:|.|:.|...:..::.|:..|:
  Fly   338 CG----------SSSPWMLGAFIVNEMKTISEDDV------------------------------ 362

  Fly   191 FAWHGRTQTAEGSGKRDDGEMEEEEPPGQQIQATDDEDLPSIESFLGGMNLYMNTELTLAKRMSE 255
                      |...|.::.:::|.   ||:|
  Fly   363 ----------EPHFKTENMKLDEY---GQRI---------------------------------- 380

  Fly   256 AAHYTLFDVWNPGLNYGGHVNLTEIGSFTPTEGIQ---LHTWFRTTSTVRRRMDMQHARVRCMVV 317
              |:.| :::.|.:|....|       :||..||:   |:....:..|.:   |....| :...|
  Fly   381 --HFNL-EIYKPTVNEPMMV-------WTPDNGIKKRLLNLELESAGTTQ---DFSEQR-KVYTV 431

  Fly   318 VT------------NKNMTGTLMYYLTHTMSGH-IDTMNRFNFNLLMAVRDMFNWTFVLSRTTSW 369
            ||            ::|..|...|      .|: :|.:::  .:.||.    |::.|::......
  Fly   432 VTHYEEPYFMMKEDHENFRGREKY------EGYAVDLISK--LSELME----FDYEFMIVNGNGK 484

  Fly   370 GYVKNGRFDGMIGALIRNETDIGGAPIFYWLERHKWID---------VAGRSWSSRPCFIFRHPR 425
            ...:..::||:|..||.:...||...:.....|...:|         ::...:.|.|
  Fly   485 YNPETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPP-------- 541

  Fly   426 STQKDRIVFLQPFTNDVWILIVGCGVLTVFILWFLTTI---EWKLVPHDGSALIKPKGGAPPRHH 487
             ..|::..||:||..:|||.::...::......|:..:   ||                .||...
  Fly   542 -EPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREW----------------LPPNPA 589

  Fly   488 YQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAK 552
            .|...:.|.:                                     |     .:|
  Fly   590 IQDPDELENI-------------------------------------W-----NVN--------- 603

  Fly   553 QKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLME 617
                        .|....||.|.|||..........|.:......|:..:...|:|::...|...
  Fly   604 ------------NSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSN 656

  Fly   618 K-PKTIKTLSDLVHSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKITSVPTTKENEADE----D 677
            | ..:||:|.||:.                    :|.|.........||:..::.|:.|.    :
  Fly   657 KWQSSIKSLQDLIE--------------------QDKVHFGSMRGGSTSLFFSESNDTDYQRAWN 701

  Fly   678 EPVDPNP---VSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHLGFAFHVDVAAAYKI 739
            :..|.||   .||:                  |:..|.  :..|.|     |:||.::..:.
  Fly   702 QMKDFNPSAFTSTN------------------KEGVAR--VRKEKG-----GYAFLMETTSL--- 738

  Fly   740 IAETFSEQDICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHFNVWHSRKPP 803
               |::.:..||||::.....:|...: :...|..|..:|..:.:::|.|.|....|.|...
  Fly   739 ---TYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKN--- 797

  Fly   804 CVKKIETSDLH-VDMDTVS----SALLILLFSYAITLMILGT-EILYS 845
              ..:.....| ||.|.:|    ..:.::|....:..:|||. |.|::
  Fly   798 --HNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWN 843

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:473866	23/125 (18%)
		Lig_chan	563..828	CDD:459656	55/278 (20%)
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	50/293 (17%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	91/521 (17%)
		Lig_chan	555..828	CDD:459656	68/407 (17%)