DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir64a and Ir25a

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster

Alignment Length:	703	Identity:	129/703 - (18%)
Similarity:	230/703 - (32%)	Gaps:	229/703 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 RMEALRQIAVVD-LACGAVSRRFLELASAKMLYSEKFHWLLIEDFAWHGRTQT-AEGSGKRDDGE 210
            ::|.||.:.:.: ...|.:....:.|.|.|..|.|:       :||||..||. .|.|.:||:..
  Fly   222 QIEKLRNLDINNFFILGTLQSIRMVLESVKPAYFER-------NFAWHAITQNEGEISSQRDNAT 279

  Fly   211 MEEEEPPGQQ--------IQAT----DDEDLPSIESFLGGMNLYMNTELTLAKRMSEAAHYTLFD 263
            :...:|....        ::.|    ::..|.|...|    :|.:.:.||:.:.:...|
  Fly   280 IMFMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYF----DLALRSFLTIKEMLQSGA------ 334

  Fly   264 VWNPGLNYGGHVNLTEI-GSFTPTEGIQLHTWFR--------------TTST--------VRRRM 305
             |...:.|   :|..:. |..||...:.|..:|.              |.||        ::..|
  Fly   335 -WPKDMEY---LNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEM 395

  Fly   306 DMQHARVR------------------CMVVVTN----KNMTGTLMYYLTHTM------------- 335
            |:...::|                  ..::|.:    ||:|...:|.:...:
  Fly   396 DINVLQIRGGSSVNSKSIGKWISGLNSELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDETAPK 460

  Fly   336 --SGH-IDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWGYV-KNGRFDGMIGALIRNETDIGGAPI 396
              .|: ||.:|.      :|....|::|........:|.: :||:::|::..|:..:.|||...:
  Fly   461 GYKGYCIDLINE------IAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSM 519

  Fly   397 FYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVWILIVGCGVLTVFILWFLT 461
            ....||...||.....:......|.....|:......||.....:||:.|:.....|.|::|...
  Fly   520 SVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFD 584

  Fly   462 TIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDS 526
              .|                :|    |..|..:|                 |.|.:|::.|:.
  Fly   585 --RW----------------SP----YSYQNNRE-----------------KYKDDEEKREFN-- 608

  Fly   527 TPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCI 591
                                                ..|.:.|.:..:..||.|.:...:|||.:
  Fly   609 ------------------------------------LKECLWFCMTSLTPQGGGEAPKNLSGRLV 637

  Fly   592 VITSLLFSFCIYQFYSASIVGTLLMEKPKT-IKTLSDLVH-----------SSLKVGMEDILYNR 644
            ..|..||.|.|...|:|::...|.:.:..| :::|.||..           ||.....|.:....
  Fly   638 AATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIE 702

  Fly   645 DYFLHTKDPVSMELYAKKITSVPTTKENEADEDEPVDPNPVSTDPAKSYRDIVHS------HETG 703
            ..|......:|:.   ..:|:|..:|....|       .|||....|.::.:..:      .|..
  Fly   703 QMFYEIWKDLSLN---DSLTAVERSKLAVWD-------YPVSDKYTKMWQAMQEAKLPATLDEAV 757

  Fly   704 AHAKDNAASNWLDPETGLLRHLGFAFHVDVA---------AAYKIIAETFSEQ 747
            |..:::.|:.            ||||..|..         ...:::.|.||.:
  Fly   758 ARVRNSTAAT------------GFAFLGDATDIRYLQLTNCDLQVVGEEFSRK 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	25/114 (22%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	44/212 (21%)
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	42/224 (19%)
		PBP2_iGluR_putative	438..836	CDD:270435	83/466 (18%)
		Lig_chan	565..870	CDD:278489	59/333 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462980
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840