DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir64a and GluRIIE

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster

Alignment Length:	958	Identity:	163/958 - (17%)
Similarity:	300/958 - (31%)	Gaps:	304/958 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LELELDYGLAEPQRTSL---LQSSLILQFSQDYKH-------------IPRITYFTCQKPHLQTP 70
            |:.|::||.|......|   |::.:...|....:|             ||.|  ::....:.:..
  Fly    74 LKEEVNYGDAYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHI--YSYMSENAEGF 136

  Fly    71 NQIPNAAEHRDAFAAKNFQLIKS--------LYESELFVRIV--LLDVLAQSPTSGRPNRPGNGP 125
            |..|:.|:    .|...:.||..        ||||..::.|:  |..:|.:|.|.
  Fly   137 NLHPHPAD----LAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTV---------- 187

  Fly   126 TGGFSQTPSQAQSNSEWLEGVLRMEALRQIAVVDLACGAVSRRFLELASAKMLYSEKFHWLL--- 187
               .:......|.|..:.:.:.|:.......:|.:........||..|....:.:|.:.:::
  Fly   188 ---ITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNL 249

  Fly   188 ------IEDFAWHGRTQTAEGSGKR--------------------DDGEMEEEEPP--------- 217
                  :|::.:    ..|..:|.|                    |..|......|
  Fly   250 DFHSFDLEEYKY----SEANITGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTY 310

  Fly   218 -GQQIQATDDEDLP-------------SIESFLGGMNLYMNTELTLAKRMSEAAHYTLFDVWNPG 268
             ..|:.|...::||             |:.........||.| |.|..|:.....|     :...
  Fly   311 DAVQLFAQTLKNLPFKPMPQNCSQRTESVRDDGSSFKNYMRT-LRLTDRLLTGPIY-----FEGN 369

  Fly   269 LNYGGHVNLTEIGSFTPTEGIQLHTWFRTTSTVRRRMDMQHA----------------------R 311
            :..|.|:::.|:   .|:..:::.||........:|:....|                      :
  Fly   370 VRKGYHLDVIEL---QPSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNK 431

  Fly   312 VRCMVVVTNKNMTGTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDM--FNWTFVLSRTTSWGYVKN 374
            ....:|.|.|.:.|...|             ..:..:|:..:.|.  ||:|||........|.|:
  Fly   432 PYAQLVETYKQLEGNSQY-------------EGYGVDLIKELADKLGFNFTFVNGGNDYGSYNKS 483

  Fly   375 -GRFDGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVFLQPF 438
             ....||:..::....|:....:....||.:.:|......:.....::..|:....:...|:.||
  Fly   484 TNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPF 548

  Fly   439 TNDVWILI----VGCGVLTVFILWFLTTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEA 499
            :.:||..:    :|.. |:.|||..|:..||.
  Fly   549 SEEVWWFLGFSFLGVS-LSFFILGRLSPSEWD--------------------------------- 579

  Fly   500 PVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVGLFL 564
              .|...:          |:.||.|:...: ..::|
  Fly   580 --NPYPCI----------EEPEELENQFTL-GNSIW----------------------------- 602

  Fly   565 ESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLMEKPKT-IKTLSDL 628
                |..|.:.|||.......:|.|.:......|:..:...|:|::...|.:|||:: |.::.||
  Fly   603 ----FTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDL 663

  Fly   629 -------VHSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKITSVPTTKENEADEDEPVDPNPVS 686
                   |:.:.|.|.     .|::|:     .|.|...||:....:.......||.....|.|.
  Fly   664 ADNKDGVVYGAKKTGS-----TRNFFM-----TSAEERYKKMNKFMSENPQYLTEDNMEGVNRVK 718

  Fly   687 TDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHLGFAFHVDVAAAYKIIAETFSEQDICD 751
            |          ::|                          :||.::..:.      .::.:..|:
  Fly   719 T----------NTH--------------------------YAFLMESTSI------EYNTKRECN 741

  Fly   752 LTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHFNVWHSRKPP--CVKKIETSD- 812
            |.::.....:|...| |:|:.|.|...:..|..:.|.|:|....|.|.:....  |..|.:..|
  Fly   742 LKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDA 806

  Fly   813 LHVDMDTVSSALLILLFS------YAITLMILGTEILYSKWHNRIQLK 854
            ..:||:.:.....:||..      |.|...:|  .::....|.|:.|:
  Fly   807 TPLDMNNLEGVFFVLLVGSCCALLYGIISWVL--FVMKKAHHYRVPLR 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	26/120 (22%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	53/276 (19%)
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	60/353 (17%)
		ANF_receptor	51..382	CDD:279440	57/339 (17%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	88/515 (17%)
		Lig_chan	551..824	CDD:278489	71/404 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462825
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840