DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir64a and Nmdar2

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster

Alignment Length:	753	Identity:	132/753 - (17%)
Similarity:	235/753 - (31%)	Gaps:	250/753 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 ELASAKMLYS---EKFHWLLIEDFAWHGRTQTA-------EGSGKRDDGEM------------EE 213
            |:::|..:||   |.:    :.|.|...|..|.       ||.|:.|:||:            :.
  Fly   373 EISNAIKIYSYGVEAY----LTDPANRDRRLTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDL 433

  Fly   214 EEPPGQQIQATDDEDLPSIESFLGGMNLYMNT--------ELTLAKRMSEAAHYTLFDVWNPGLN 270
            .:|   .|:.|.|.||.|.|  |..|||..:.        |:.:.|.. |.....:.|:..||
  Fly   434 NKP---NIEFTADGDLRSAE--LKIMNLRPSANNKNLVWEEIGVWKSW-ETQKLDIRDIAWPG-- 490

  Fly   271 YGGHVNLTEIGSFTPTEGI----QLHTWFRTTSTVRRRMDMQHARVRCMV-------VVTNKNMT 324
                      .|..|.:|:    .|...|...:.............:|::       |..:..|.
  Fly   491 ----------NSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMA 545

  Fly   325 GTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNWTFVLSRTT--SWGYVKNGRFDGMIGALIRN 387
            ..:.....|.........:.|..:||....:...:|:.|.|..  .||.::||:::|:|..|:..
  Fly   546 ADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLENGKWNGLIADLVNR 610

  Fly   388 ETDIGGAPIFYWLERHKWID-------------VAGRSWSSRPCFIFRHPRSTQKDRIVFLQPFT 439
            :||:....:....||...:|             ||.|:....|              ..||:||.
  Fly   611 KTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISP--------------TAFLEPFD 661

  Fly   440 NDVWILIVGCGVLTVFILWFLTTI-EWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRP 503
            ...|:|:   |::.:....|:..: ||          :.|.|
  Fly   662 TASWMLV---GIVAIQAATFMIFLFEW----------LSPSG----------------------- 690

  Fly   504 ITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVGLF----- 563
                               |:                 :..|:::...    .|.|..||
  Fly   691 -------------------YD-----------------MKLYLQNTNV----TPYRFSLFRTYWL 715

  Fly   564 LESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLL-MEKPKTIKTLSD 627
            :.:|||...:......||::.|::.     ...||:......|:|::...:: .|:......|:|
  Fly   716 VWAVLFQAAVHVDSPRGFTSRFMTN-----VWALFAVVFLAIYTANLAAFMITREEFHEFSGLND 775

  Fly   628 --LVHSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKITSVPTTKENEADEDEPVDPNPVSTDPA 690
              |||                                                     |.|..|:
  Fly   776 SRLVH-----------------------------------------------------PFSHKPS 787

  Fly   691 KSYRDIVHSH-ETGAHAKDNAASNWL---------DPETGLLRHLGFAFHVDVAAAYKIIAETFS 745
            ..:..|.:|| ::..|...|...|::         |....:|.....:|..|......::|:
  Fly   788 FKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNGNLDSFIYDGTVLDYLVAQ--- 849

  Fly   746 EQDICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHFNVWHSRKPPCVKKIE 809
            ::| |.|..|..:.......: ..:||...::.:..|......|.|......|.:......|:..
  Fly   850 DED-CRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEH 913

  Fly   810 TSDLHVDMDTVSSALLILLFSYAITLMILGTEILYSKW 847
            .|...:.::...||.|:|:....:..::|..|.:|.|:
  Fly   914 KSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFKY 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	27/129 (21%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	46/283 (16%)
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	31/126 (25%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	86/557 (15%)
		Lig_chan	665..928	CDD:278489	57/400 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462956
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840