DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir64a and GRIN2B

DIOPT Version :10

Sequence 1:NP_647962.1 Gene:Ir64a / 38616 FlyBaseID:FBgn0035604 Length:859 Species:Drosophila melanogaster
Sequence 2:NP_000825.2 Gene:GRIN2B / 2904 HGNCID:4586 Length:1484 Species:Homo sapiens


Alignment Length:628 Identity:105/628 - (16%)
Similarity:179/628 - (28%) Gaps:242/628 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   280 IGSFTPTEGIQLHTWFRTTSTVRRRMDMQHARVRCMVVVTNKNMTGTLMYYLTHTMSGHIDTMNR 344
            :.|..|..|    |..|.|             |.|...:..:|.|.....|:.....|       
Human   419 VESVDPLSG----TCMRNT-------------VPCQKRIVTENKTDEEPGYIKKCCKG------- 459

  Fly   345 FNFNLLMAVRDMFNWTFVLSRTTSWGYVK--NGRFDGMIGALIRNETDIGGAPIFYWLERHKWID 407
            |..::|..:.....:|:.|...|:..:.|  ||.::||||.::.....:....:....||.:.:|
Human   460 FCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVD 524

  Fly   408 VAGRSWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVWI------LIVGCGVLTVF----------- 455
            .:.....:....:......|.... .||:||:.|||:      |||....:.||           
Human   525 FSVPFIETGISVMVSRSNGTVSPS-AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRC 588

  Fly   456 ----------------ILWFLTTIEWKLVPHDGSALIKPKGG----------------------- 481
                            .:|.|    |.||.::...:..|||.                       
Human   589 LADGREPGGPSFTIGKAIWLL----WGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTAN 649

  Fly   482 ----------------------------APP---------------------RHHYQQQQQQEQV 497
                                        :||                     .|.|..:..|..|
Human   650 LAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGV 714

  Fly   498 E--------------------------------------APVRPITAVSVVVSKEKVEEKQEE-- 522
            :                                      ..|...|...:.:.|:...::|.:  
Human   715 DDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLA 779

  Fly   523 ----YEDSTPIDAGTLWQR--CYQKLNKYIKDRKAKQKKAPERVGLF----LESVLFFVGIICQQ 577
                :.|....:...||..  |:.:.|:.:    :.|.......|:|    ....|..:..||:.
Human   780 ILQLFGDGEMEELEALWLTGICHNEKNEVM----SSQLDIDNMAGVFYMLGAAMALSLITFICEH 840

  Fly   578 GL--GFSTSFVSGRCIVITSLLFSF------CIY-------QFYSASIVGTL------LMEKPKT 621
            ..  .|...|: |.|.....::||.      ||:       |....|...|:      ::...:|
Human   841 LFYWQFRHCFM-GVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLLRT 904

  Fly   622 IKTLSDL--VHSSLKVGME---------DILYNRDYFLHT------KDPVSMELYAKKITSVPTT 669
            .|.:::|  |:.|.:..::         ||..:|..|.|:      ..|....|::..|:.|..|
Human   905 AKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFSDYISEVERT 969

  Fly   670 KENEADEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAKDNAAS 712
            ..|...:|..|            |:|..|.|.. .|:..:|:|
Human   970 FGNLQLKDSNV------------YQDHYHHHHR-PHSIGSASS 999

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir64aNP_647962.1 Periplasmic_Binding_Protein_Type_2 351..>465 CDD:473866 28/148 (19%)
Lig_chan 563..828 CDD:459656 40/192 (21%)
GRIN2BNP_000825.2 PBP1_iGluR_NMDA_NR2 33..388 CDD:380601
PBP2_iGluR_NMDA_Nr2 403..803 CDD:270436 62/412 (15%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:A7XY94 604..623 5/22 (23%)
NMDAR2_C 840..1484 CDD:463148 36/174 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1074..1097
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1161..1194
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1271..1301
Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097 1292..1304
PDZ-binding. /evidence=ECO:0000250 1482..1484
Blue background indicates that the domain is not in the aligned region.

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