DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir64a and GRIN2A

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	XP_016878661.1	Gene:	GRIN2A / 2903	HGNCID:	4585	Length:	1516	Species:	Homo sapiens

Alignment Length:	731	Identity:	130/731 - (17%)
Similarity:	231/731 - (31%)	Gaps:	244/731 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 LELASAKMLYSEKFHWLLIEDFAWHGRTQTAEGSGKRDDGEMEEEEPPGQQIQ------ATDDED 228
            |..|::.||  |||.::           ..|:.|..   |:||..|.|...:.      ..|.:|
Human   351 LTTAASSML--EKFSYI-----------PEAKASCY---GQMERPEVPMHTLHPFMVNVTWDGKD 399

  Fly   229 LPSIESFLGGMNLY-------MNTEL-----------TLAKRMSEAAHYTLFDVWNPGLNYGGHV 275
            |...|.   |..::       :|.:.           ||:.|.:....|..|....|..|:...|
Human   400 LSFTEE---GYQVHPRLVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIV 461

  Fly   276 NLTEIGSFTPTEGIQ--LHTWFRTTSTVRRRMDMQHARVRCMVVVTNKNMTGTLMYYLTHTMSGH 338
            .|.| ..|...|.|.  ..|..|.|...|:.:.:.::        ||:.|.      :.....|.
Human   462 TLEE-APFVIVEDIDPLTETCVRNTVPCRKFVKINNS--------TNEGMN------VKKCCKGF 511

  Fly   339 -IDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWGY----VKNGR--------FDGMIGALIRNETD 390
             ||.:.:                  ||||..:.|    |.||:        ::||||.::.....
Human   512 CIDILKK------------------LSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAV 558

  Fly   391 IGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVWILIVGCGVLTVF 455
            :....:....||.:.:|.:.....:....:......|.... .||:||:..||::        :|
Human   559 MAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPS-AFLEPFSASVWVM--------MF 614

  Fly   456 ILWFLTTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQ 520
            ::..:                                           ::|::|.|
Human   615 VMLLI-------------------------------------------VSAIAVFV--------- 627

  Fly   521 EEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSF 585
              :|..:|:.                .:|...:.|||......:...::.:     .||.|:.|.
Human   628 --FEYFSPVG----------------YNRNLAKGKAPHGPSFTIGKAIWLL-----WGLVFNNSV 669

  Fly   586 -------VSGRCIVITSLLFSFCIYQFYSASIVGTLLMEKPKTIKTLSDLVHSSLKVGMEDILYN 643
                   .:.:.:|.....|:......|:|::...::.|:      ..|.|     .|:.|..:.
Human   670 PVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEE------FVDQV-----TGLSDKKFQ 723

  Fly   644 RDYFLHTKDPVSMELYAKKITSVPT-TKENEADEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAK 707
            |.   |...|      ..:..:||. :.|.....:.|.....::....|...|.:.|.:||.
Human   724 RP---HDYSP------PFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGK--- 776

  Fly   708 DNAASNWLDPETGLLRHLGFAFHVDVAAA-YKIIAETFSEQDICDLTEVS---MFPPQKTVSIMQ 768
                   ||           ||..|.|.. ||.     ...:.|.|..:.   :|........:|
Human   777 -------LD-----------AFIYDAAVLNYKA-----GRDEGCKLVTIGSGYIFATTGYGIALQ 818

  Fly   769 KNSPMRKVISYGLRRVTETGILTYHFNVW-----HSRKPPCVKKIETSDLHVDMDTVSSALLILL 828
            |.||.::.|...|.:....|.:.....:|     |:.|    .::.:|.|  |:|.::....:|.
Human   819 KGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEK----NEVMSSQL--DIDNMAGVFYMLA 877

  Fly   829 FSYAITLMILGTEILY 844
            .:.|::|:....|.|:
Human   878 AAMALSLITFIWEHLF 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	23/125 (18%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	50/281 (18%)
GRIN2A	XP_016878661.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156032
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740