DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir64a and GRIK4

DIOPT Version :9

Sequence 1:NP_647962.1 Gene:Ir64a / 38616 FlyBaseID:FBgn0035604 Length:859 Species:Drosophila melanogaster
Sequence 2:NP_001269399.1 Gene:GRIK4 / 2900 HGNCID:4582 Length:956 Species:Homo sapiens


Alignment Length:662 Identity:118/662 - (17%)
Similarity:210/662 - (31%) Gaps:243/662 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   264 VWNPG---LNY---------GGHVNLT---------------------EIGSFTPTEGIQL---- 291
            :|..|   :||         .||:...                     :||.:...||:.:    
Human   340 IWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHL 404

  Fly   292 ------HTWFRTTSTVRRRMDMQHARVRCMVVVTNKNMTGTLMYYLTH-TMSGHIDTMNRFNFNL 349
                  .|.|.||                 :|||.......||....| .|.|: |....|..::
Human   405 YASNISDTLFNTT-----------------LVVTTILENPYLMLKGNHQEMEGN-DRYEGFCVDM 451

  Fly   350 LMAVRDM--FNWTFVLSRTTSWGYVK-NGRFDGMIGALIRNETDIGGAPIFYWLERHKWIDVAGR 411
            |..:.::  ||:...|.....:|..: ||.:.||:|.||..:.|:..|.:....||.|.||.:..
Human   452 LKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKP 516

  Fly   412 SWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVWI------LIVGCGVLTVFILWFLTTIEWKLVPH 470
            ..:.....::|.....:.....||.||:..||:      |.|.|   .:|::..||..|| ..||
Human   517 FMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSC---VLFLVARLTPYEW-YSPH 577

  Fly   471 DGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLW 535
                                                                     |...|   
Human   578 ---------------------------------------------------------PCAQG--- 582

  Fly   536 QRCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSF 600
             ||...:|:|             .:|   .|:.|.||...|||...:...:|.||:......|:.
Human   583 -RCNLLVNQY-------------SLG---NSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTL 630

  Fly   601 CIYQFYSASIVGTLLMEKPKT-IKTLSDLV-HSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKI 663
            .|...|:|::...|.:::... |:::.||. .::::.|......:..:|.:::......::    
Human   631 IIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMW---- 691

  Fly   664 TSVPTTKENEADEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHL--G 726
                                           :.::|.:.....|..        |.|:.|.|  .
Human   692 -------------------------------NYMYSKQPSVFVKST--------EEGIARVLNSN 717

  Fly   727 FAFHVDVAAAYKIIAETFSE---QDICDLTEV----------------SMFPPQKTVSIMQKNSP 772
            :||         ::..|.:|   |..|:||::                |:|..:..::|:|....
Human   718 YAF---------LLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQEN 773

  Fly   773 MRKVISYGLRRVTETGILTYHFNVWHSRKPPCVKKIETSDLHVDMDTVSSALLILLFSYAITLMI 837
            .|..|   |:|           ..|...|  |.|:.:.....:.|:.:....::|:....:.:.:
Human   774 NRLEI---LKR-----------KWWEGGK--CPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFM 822

  Fly   838 LGTEILYSKWHN 849
            ...|.|::..|:
Human   823 AMLEFLWTLRHS 834

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir64aNP_647962.1 Periplasmic_Binding_Protein_Type_2 351..>465 CDD:304360 31/122 (25%)
Lig_chan 563..828 CDD:278489 47/287 (16%)
GRIK4NP_001269399.1 PBP1_iGluR_Kainate_KA1_2 26..400 CDD:107389 10/59 (17%)
ANF_receptor 43..382 CDD:279440 6/41 (15%)
PBP2_iGluR_kainate_KA1 415..785 CDD:270442 97/534 (18%)
Lig_chan 547..816 CDD:278489 67/417 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..889
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 931..956
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155767
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18966
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.840

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