Protein Alignment Ir64a and GRIK3

DIOPT Version :9

• Sequence 1: NP_647962.1
• Gene: Ir64a / 38616
• FlyBaseID: FBgn0035604
• Length: 859
• Species: Drosophila melanogaster
• Sequence 2: NP_000822.2
• Gene: GRIK3 / 2899
• HGNCID: 4581
• Length: 919
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 102/582 - (17%)
• Similarity: 200/582 - (34%)
• Gaps: 152/582 - (26%)

  Fly   277 LTEIGSFTPTEGIQLHTWFRTTSTVRRRMDMQHARVRCMVVVTNKNMTGTLMYYLT-HTMSGHID 340
            |.::|.::|.:|:.:     |.....|..::..:.....::||.......:|:..: .|:.|: |
Human   402 LEKVGVWSPADGLNI-----TEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGN-D 460

  Fly   341 TMNRFNFNLLMAVRDMFNWTFVLSRTTSWGY---VKNGRFDGMIGALIRNETDIGGAPIFYWLER 402
            ....:..:||..:..:..:::.:.......|   ...|:::||:..||.::.|:..||:.....|
Human   461 RFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVR 525

  Fly   403 HKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVW--ILIVGCGVLTV-FILWFLTTIE 464
            .|.||.:....:.....::|.|..|......||.|.:.|:|  :|:...||..| |::...:..|
Human   526 EKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYE 590

  Fly   465 WKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPI 529
            |                                                          .|:.|.
Human   591 W----------------------------------------------------------YDAHPC 597

  Fly   530 DAGTLWQRCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVIT 594
            :.|:                     :..|.....|.|..|.:|.:.|||.......:|.|.|...
Human   598 NPGS---------------------EVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGI 641

  Fly   595 SLLFSFCIYQFYSASIVGTLLMEKPKT-IKTLSDLV-HSSLKVGMEDILYNRDYFLHTKDPVSME 657
            ...|:..|...|:|::...|.:|:.:: |.:..||. .:.::.|.            .||..:|.
Human   642 WWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGA------------VKDGATMT 694

  Fly   658 LYAKKITSVPTTKENEADEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLL 722
            .:.|  :.:.|.::..|.         :|:.|:             |..|:|        |.|:.
Human   695 FFKK--SKISTFEKMWAF---------MSSKPS-------------ALVKNN--------EEGIQ 727

  Fly   723 RHLGFAFHVDVAAAYKIIAET----FSEQDICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLR 782
            |.|        .|.|.::.|:    :..|..|:||::......|...| ....||.|..|:..:.
Human   728 RAL--------TADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAIL 784

  Fly   783 RVTETGILTYHFNVWHSRKPPCVKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILY 844
            ::.|...|......|. |...|.::.......:.:..:....::|.....:::::...|.:|
Human   785 QLQEEDKLHIMKEKWW-RGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVY 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	26/119 (22%)
		Lig_chan	563..828	CDD:278489	53/271 (20%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	4/19 (21%)
		ANF_receptor	55..398	CDD:279440
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	91/500 (18%)
		Lig_chan	564..832	CDD:278489	67/399 (17%)
		Glutamate binding. /evidence=ECO:0000250	690..692		0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156111
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740