back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir64a and GRIK2

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	898	Identity:	161/898 - (17%)
Similarity:	291/898 - (32%)	Gaps:	289/898 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PHLQT--PNQIPNAAEHRDAFAAKNFQLIKSLYESEL----FVR-------------IVLLDVLA 110
            ||:||  .:|:   ::::|:|....:....||..:.|    |.:             ::.|..|.
Human   128 PHIQTRWKHQV---SDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELI 189

  Fly   111 QSPTSGRPNRPGNGPTGGFSQTPSQAQSNSEWLEGVLRMEALRQIAVV-----DLACGAVSRRFL 170
            ::|:  |.|....     ..|.|:..:.....|:   .|:..::..|:     ::|.|     .|
Human   190 KAPS--RYNLRLK-----IRQLPADTKDAKPLLK---EMKRGKEFHVIFDCSHEMAAG-----IL 239

  Fly   171 ELASAKMLYSEKFHWLL---------IEDFAWHG---------RTQTAEGSGKRDDGEMEEEEPP 217
            :.|.|..:.:|.:|::.         :|.:.:.|         .|:..:.|...:...||..:.|
Human   240 KQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAP 304

  Fly   218 GQQIQATDDEDLPSIESFLGGMNLYMNTELTLAKRMSEAAHYTLFDV------------------ 264
                        |..:|  |.::.:|.|:..|   |.:|.|.....|
Human   305 ------------PKPDS--GLLDGFMTTDAAL---MYDAVHVVSVAVQQFPQMTVSSLQCNRHKP 352

  Fly   265 WNPGLNY------------GGHV----------------------NLTEIGSFTPTEGIQLHTWF 295
            |..|..:            .|.:                      .|.:||::.|..|:.:
Human   353 WRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNM---- 413

  Fly   296 RTTSTVRRRMDMQHA-RVRCMVVVTNKNMTGTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNW 359
             |.|...:..::..: ..|.::|.|.......|.......:.|: |....:..:||..:..:..:
Human   414 -TESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGN-DRFEGYCIDLLRELSTILGF 476

  Fly   360 TFVLSRTTSWGY----VKNGRFDGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFI 420
            |:.:.......|    ..||:::||:..||.::.|:..||:.....|.|.||.:....:.....:
Human   477 TYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISIL 541

  Fly   421 FRHPRSTQKDRIVFLQPFTNDVW--ILIVGCGVLTV-FILWFLTTIEWKLVPHDGSALIKPKGGA 482
            :|.|..|......||.|.:.|:|  ||:...||..| |::...:..|| ..||
Human   542 YRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEW-YNPH------------ 593

  Fly   483 PPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIK 547
                             |..|                     ||..::            |.:
Human   594 -----------------PCNP---------------------DSDVVE------------NNF-- 606

  Fly   548 DRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVG 612
                          ..|.|..|.||.:.|||.......:|.|.:......|:..|...|:|::..
Human   607 --------------TLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAA 657

  Fly   613 TLLMEKPKT-IKTLSDLV-HSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKITSVPTTKENEAD 675
            .|.:|:.:: |.:..||. .:.::.|.            .:|..:|..:.|
Human   658 FLTVERMESPIDSADDLAKQTKIEYGA------------VEDGATMTFFKK-------------- 696

  Fly   676 EDEPVDPNPVST-DPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHLGFAFHVDVAAAYKI 739
                   :.:|| |...::   :.|.......|.|        |.|:.|.|        .:.|..
Human   697 -------SKISTYDKMWAF---MSSRRQSVLVKSN--------EEGIQRVL--------TSDYAF 735

  Fly   740 IAET----FSEQDICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHF---NV 796
            :.|:    |..|..|:||::......|...: ....||.|..|:..:.::.|.|.|  |.   ..
Human   736 LMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKL--HMMKEKW 798

  Fly   797 WHSRKPPCVKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILYSKWHN 849
            |.....|..:..|.|.|.|  ..:....::|.....:::.:...|.||....|
Human   799 WRGNGCPEEESKEASALGV--QNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKN 849

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.