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Protein Alignment Ir64a and GRIK1

DIOPT Version :9

Sequence 1:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001317923.1	Gene:	GRIK1 / 2897	HGNCID:	4579	Length:	949	Species:	Homo sapiens

Alignment Length:	759	Identity:	137/759 - (18%)
Similarity:	249/759 - (32%)	Gaps:	215/759 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 PNRPGNGPTGGFSQTPSQAQSNSEWLEGVLRMEALRQIAVVDLAC-----GAVSRRFLELASAKM 177
            |.||..|...|...|.:....::.::..:....| .|:.|..|.|     ..:..||:.
Human   305 PPRPETGLLDGMMTTEAALMYDAVYMVAIASHRA-SQLTVSSLQCHRHKPWRLGPRFMN------ 362

  Fly   178 LYSEKFHWLLIEDFAWHGRTQTAEGSGKRDDGEMEEEEPPGQQIQATDDEDLPSIESFLGGMNLY 242
                     ||::..|.|.|           |.:...:..|  ::...|.|:.|::.
Human   363 ---------LIKEARWDGLT-----------GHITFNKTNG--LRKDFDLDIISLKE-------- 397

  Fly   243 MNTELTLAKRMSEAAHYTLFDVWNPGLNYGGHVNLTEIGSFTPTEGIQLHTWFRTTSTVRRRMDM 307
            ..||    |...|.:.: |:.||.            :||.:....|:.:     |.|...:..::
Human   398 EGTE----KAAGEVSKH-LYKVWK------------KIGIWNSNSGLNM-----TDSNKDKSSNI 440

  Fly   308 QHARVRCMVVVTNKNMTGTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWGY- 371
            ..:.....::||.......:||..:.......|....:..:||..:.::..:.:.:.......|
Human   441 TDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYG 505

  Fly   372 VKN--GRFDGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVF 434
            .:|  |.::||:..||.:..|:..||:.....|.|.||.:....:.....::|.|..|......|
Human   506 AQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSF 570

  Fly   435 LQPFTNDVW--ILIVGCGVLTV-FILWFLTTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQ 496
            |.|.:.|:|  :|:...||..| |::...|..|| ..||
Human   571 LNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEW-YNPH-------------------------- 608

  Fly   497 VEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVG 561
               |..|                     ||..::            |.:
Human   609 ---PCNP---------------------DSDVVE------------NNF---------------- 621

  Fly   562 LFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLMEKPKT-IKTL 625
            ..|.|..|.||.:.|||.......:|.|.:......|:..|...|:|::...|.:|:.:: |.:.
Human   622 TLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSA 686

  Fly   626 SDLV-HSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKITSVPTTKENEADEDEPVDPNPVSTDP 689
            .||. .:.::.|.            .:|..:|..:.|  :.:.|.::..|
Human   687 DDLAKQTKIEYGA------------VRDGSTMTFFKK--SKISTYEKMWA--------------- 722

  Fly   690 AKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHLGFAFHVDVAAAYKIIAETFS----EQDIC 750
                  .:.|.:                :|.|:|:........:...|.::.|:.|    .|..|
Human   723 ------FMSSRQ----------------QTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNC 765

  Fly   751 DLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHF---NVWHSRKPPCVKKIETS 811
            :||::......|...: ....||.|..|:..:.::.|.|.|  |.   ..|.....|.....|.|
Human   766 NLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKL--HMMKEKWWRGNGCPEEDNKEAS 828

  Fly   812 DLHVDMDTVSSALLILLFSYAITLMILGTEILY-SKWHNRIQLK 854
            .|.|  :.:....::|.....:::.:...|.:| |:.:|.|:.|
Human   829 ALGV--ENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQK 870

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.